Cho S Y, Choi H Y
Am J Clin Pathol. 1979 Oct;72(4):617-21. doi: 10.1093/ajcp/72.4.617.
A high incidence of opportunistic fungal infections among cancer patients has been a pressing problem confronting clinicians. The fungal infections in 3,278 consecutive autopsies at Thomas Jefferson University Hospital during a ten-year period (1966-1975) were studied. There were 1,204 (36.7%) cancer patients; 85 (7.1%) of these patients had concomitant fungal infections. The incidence was 9.3% during the last five-year period; 5.1% during the first five-year period. Candidiasis was the most frequent fungal infection (52.2%) among these patients, followed by aspergillosis (31.1%), mucormycosis, cryptococcosis, histoplasmosis and nocardiosis. The leukemias and lymphomas were the most frequent malignancies associated with fungal infections. However, in this study, unlike others, the incidences of fungal infection in patients with some solid tumors were also high, especially those in patients with cancers of the colon and pancreas.
癌症患者中机会性真菌感染的高发病率一直是临床医生面临的紧迫问题。对托马斯·杰斐逊大学医院在十年期间（1966 - 1975年）连续进行的3278例尸检中的真菌感染情况进行了研究。其中有1204例（36.7%）癌症患者；这些患者中有85例（7.1%）伴有真菌感染。在最后五年期间发病率为9.3%；在前五年期间为5.1%。念珠菌病是这些患者中最常见的真菌感染（52.2%），其次是曲霉病（31.1%）、毛霉菌病、隐球菌病、组织胞浆菌病和诺卡菌病。白血病和淋巴瘤是与真菌感染相关最常见的恶性肿瘤。然而，在本研究中，与其他研究不同的是，一些实体瘤患者的真菌感染发生率也很高，尤其是结肠癌和胰腺癌患者。
