铜绿假单胞菌中通过突变为链霉素抗性来抑制对氟苯丙氨酸的抗性
Suppression of fluorophenylalanine resistance by mutation to streptomycin resistance in Pseudomonas aeruginosa.
作者信息
Waltho J A, Holloway B W
出版信息
J Bacteriol. 1966 Jul;92(1):35-42. doi: 10.1128/jb.92.1.35-42.1966.
Abstract
Waltho, Judith A. (University of Melbourne, Victoria, Australia), and B. W. Holloway. Suppression of fluorophenylalanine resistance by mutation to streptomycin resistance in Pseudomonas aeruginosa. J. Bacteriol. 92:35-42. 1966.-Fluorophenylalanine-resistant mutants (fpa-r) of Pseudomonas aeruginosa have been isolated. By cotransduction analysis, the mutations were shown to have at least two chromosomal locations. One locus (fpaA) showed linkage to three other markers, str, try-3bi, and arg-3, and the order of these four linked markers was found to be try-3bi, arg-3, fpaA, str. The linkage relationships of the other fpa loci are not yet known. The phenotypic expression of resistance at the fpaA locus can be suppressed by mutation of the str locus from str-s to str-r, whereas that at an unlinked fpa locus cannot.
摘要
沃尔托，朱迪思·A.（澳大利亚维多利亚州墨尔本大学）和B.W.霍洛韦。铜绿假单胞菌中链霉素抗性突变对氟苯丙氨酸抗性的抑制作用。《细菌学杂志》92:35 - 42。1966年。——已分离出铜绿假单胞菌的氟苯丙氨酸抗性突变体（fpa - r）。通过共转导分析表明，这些突变至少有两个染色体位点。一个位点（fpaA）显示与其他三个标记物str、try - 3bi和arg - 3连锁，并且发现这四个连锁标记物的顺序为try - 3bi、arg - 3、fpaA、str。其他fpa位点的连锁关系尚不清楚。fpaA位点的抗性表型表达可通过将str位点从str - s突变为str - r来抑制，而在不连锁的fpa位点则不能。
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