胎猴及新生恒河猴免疫反应的发育。I. 对牛血清白蛋白的反应
Development of the immune response in the foetal and newborn rhesus monkey. I. Response to bovine serum albumin.
作者信息
Cotes P M, Hobbs K R, Bangham D R
出版信息
Immunology. 1966 Sep;11(3):185-98.
Abstract
- Foetal rhesus monkeys (at 10–16 weeks gestation) were treated with bovine serum albumin (BSA) and subsequently, as neonates, were tested for immunity or tolerance. 2. Five out of six monkeys treated with 100 mg BSA were tolerant to BSA at challenge. 3. Some foetuses responded to treatment with 1–8 mg BSA in adjuvant with formation of antibody. 4. One monkey treated with a total of 350 mg BSA during the first 3 weeks after birth was tolerant to BSA at challenge; two other neonatal monkeys treated with 100 mg BSA did not show tolerance.
摘要
- 将妊娠10 - 16周的恒河猴胎儿用牛血清白蛋白（BSA）进行处理，随后在其出生后作为新生儿检测其免疫或耐受情况。2. 用100毫克BSA处理的六只猴子中有五只在受到攻击时对BSA具有耐受性。3. 一些胎儿在用1 - 8毫克BSA佐剂处理后产生抗体反应。4. 一只在出生后的前三周内总共接受了350毫克BSA处理的猴子在受到攻击时对BSA具有耐受性；另外两只用100毫克BSA处理的新生猴子未表现出耐受性。
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