Hervey E J
Immunology. 1966 Dec;11(6):589-95.
Rats given killed at birth produced specific agglutinins from 7 to 10 days of age and consistently thereafter. When the antigen was given to foetal rats, at least 10 days elapsed before specific agglutinins could be detected. Rats given prenatal and neonatal injections of antigen, or single concentrated doses of antigen at birth, did not develop specific agglutinins before 8 or 9 days of age, but both forms of treatment induced higher titres of antibody. The implications of these results are discussed.
出生时被杀死的大鼠在7至10日龄时产生特异性凝集素，此后一直持续产生。当给胎鼠注射抗原时，至少要经过10天才能检测到特异性凝集素。给产前和新生大鼠注射抗原，或在出生时注射单剂量浓缩抗原，在8或9日龄之前不会产生特异性凝集素，但这两种治疗方式都会诱导产生更高滴度的抗体。讨论了这些结果的意义。
