• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Separation of acetanilide and its hydroxylated metabolites and quantitative determination of "acetanilide 4-hydroxylase activity" by high-pressure liquid chromatography.

作者信息

Guenthner T M, Negishi M, Nebert D W

出版信息

Anal Biochem. 1979 Jul 1;96(1):201-7. doi: 10.1016/0003-2697(79)90573-6.

DOI:10.1016/0003-2697(79)90573-6
PMID:495983
Abstract
摘要

相似文献

1
Separation of acetanilide and its hydroxylated metabolites and quantitative determination of "acetanilide 4-hydroxylase activity" by high-pressure liquid chromatography.通过高压液相色谱法分离乙酰苯胺及其羟基化代谢物并定量测定“乙酰苯胺4-羟化酶活性”
Anal Biochem. 1979 Jul 1;96(1):201-7. doi: 10.1016/0003-2697(79)90573-6.
2
Acetanilide 4-hydroxylase and acetanilide 2-hydroxylase activity in hepatic microsomes from induced mice.
Toxicol Lett. 1991 Feb;55(2):223-31. doi: 10.1016/0378-4274(91)90137-u.
3
[Apparent Michaelis constant of acetanilide during its p-hydroxylation in liver microsomes of scorbutic guinea pigs].[坏血病豚鼠肝微粒体中对乙酰氨基酚对乙酰苯胺进行对羟基化反应时的表观米氏常数]
Hoppe Seylers Z Physiol Chem. 1970 Mar;351(3):397-400.
4
Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver.从小鼠肝脏中纯化和鉴定具有高香豆素7-羟化酶活性的微粒体细胞色素P-450
Eur J Biochem. 1984 Nov 2;144(3):425-31. doi: 10.1111/j.1432-1033.1984.tb08483.x.
5
A novel isocratic HPLC method to separate and quantify acetanilide and its hydroxy aromatic derivatives: 2-, 3- and 4-hydroxyacetanilide (paracetamol or acetaminophen).一种用于分离和定量乙酰苯胺及其羟基芳香族衍生物（2-、3-和4-羟基乙酰苯胺，即对乙酰氨基酚或醋氨酚）的新型等度高效液相色谱法。
Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):241-4. doi: 10.1007/BF03190105.
6
Enhancement of microsomal aniline and acetanilide hydroxylation by haemoglobin.血红蛋白对微粒体苯胺和乙酰苯胺羟化作用的增强
Xenobiotica. 1976 May;6(5):307-20. doi: 10.3109/00498257609151642.
7
Determination of p-nitrophenol hydroxylase activity of rat liver microsomes by high-pressure liquid chromatography.用高压液相色谱法测定大鼠肝微粒体对硝基苯酚羟化酶活性
Anal Biochem. 1993 Aug 1;212(2):311-4. doi: 10.1006/abio.1993.1335.
8
Response to 20-methylcholanthrene of hepatic aniline- and acetanilide 4-hydroxylase of rats with hypothalamic lesions.下丘脑损伤大鼠肝脏苯胺和乙酰苯胺4-羟化酶对20-甲基胆蒽的反应。
Biochim Biophys Acta. 1965 Aug 24;105(2):377-80. doi: 10.1016/s0926-6593(65)80163-1.
9
Effect of isoniazid administration on selected rat and mouse hepatic microsomal mixed-function oxidases and in vitro [14C]acetylhydrazine-derived covalent binding.异烟肼给药对选定的大鼠和小鼠肝脏微粒体混合功能氧化酶及体外[14C]乙酰肼衍生的共价结合的影响。
Biochem Pharmacol. 1982 Dec 15;31(24):4031-4. doi: 10.1016/0006-2952(82)90651-7.
10
Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.人肝微粒体及选择性表达的人细胞色素P450 3A4和3A5对17β-雌二醇向多种代谢物的NADPH依赖性代谢的表征。
J Pharmacol Exp Ther. 2001 Aug;298(2):420-32.

引用本文的文献

1
Acute toxicity, percutaneous absorption and effects on hepatic mixed function oxidase activities of 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan DP300) and its chlorinated derivatives.2,4,4'-三氯-2'-羟基二苯醚（抑菌醚DP300）及其氯化衍生物的急性毒性、经皮吸收以及对肝脏混合功能氧化酶活性的影响
Arch Environ Contam Toxicol. 1992 Jul;23(1):91-8. doi: 10.1007/BF00226000.
2
Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity.多种形式的诱导性药物代谢酶：一种任何生物体都能应对逆境的合理机制。
Mol Cell Biochem. 1979 Sep 28;27(1):27-46. doi: 10.1007/BF00849277.