Rao G N, Shaw E L, Arthur E J, Aquavella J V
Ann Ophthalmol. 1979 Jun;11(6):885-99.
In a series of 46 patients accepted for cataract removal and intraocular lens implantation, 23 showed visibly obvious variation in endothelial cell size (polymegethism) according to specular microscopic examination. In this group, mean increase in postoperative corneal thickness was 52.7% on the first postoperative day, 35.4% on the third, and 18.0% after 4 weeks. Mean corneal swelling was consistently and significantly less in the 23 patients exhibiting apparently normal endothelial cell patterns (homomegethism). In homomegethous corneas, preoperative cell density was significantly correlated with age (inversely) and postoperative cell loss (directly). Preoperative cell density in polymegethous corneas showed significant, direct correlation with age, suggesting that endothelial cell density may remain relatively constant in this condition. There was no correlation with postoperative cell loss. Significant differences in endothelial functional capability identified within each morphologically-defined group indicate a structure-function continuum. Since 15 homomegethous corneas and only one polymegethous cornea returned to preoperative thickness within 4 weeks, it appears clinically valid to use morphological criteria in predicting functional capability.
在一组46例接受白内障摘除及人工晶状体植入术的患者中，根据镜面显微镜检查，有23例显示内皮细胞大小存在明显可见的差异（多形性）。在这组患者中，术后第一天角膜厚度平均增加52.7%，第三天增加35.4%，4周后增加18.0%。在23例内皮细胞形态明显正常（等大性）的患者中，平均角膜肿胀始终且显著较小。在等大性角膜中，术前细胞密度与年龄（呈负相关）和术后细胞丢失（呈正相关）显著相关。多形性角膜的术前细胞密度与年龄呈显著正相关，这表明在此情况下内皮细胞密度可能保持相对恒定。与术后细胞丢失无相关性。在每个形态学定义的组内确定的内皮功能能力的显著差异表明存在结构 - 功能连续性。由于15例等大性角膜和仅1例多形性角膜在4周内恢复到术前厚度，因此使用形态学标准预测功能能力在临床上似乎是有效的。
