Wardrop C A, Dagg J H, Lee F D, Singh H, Dyet J F, Moffat A
Lancet. 1975 Jul 5;2(7923):4-7. doi: 10.1016/s0140-6736(75)92949-9.
Multiple immunological abnormalities have been demonstrated in fourteen patients with evidence in the blood-film of hyposplenism due to splenic atrophy. Reduction in spleen size was confirmed radiologically, and impairment of phagocytosis by the spleen was demonstrated by studying the survival and fate of chemically damaged autologous red blood-cells. Eight of the patients had intestinal malabsorption, and there was a high frequency of autoimmune disease in the remainder. Although patients with splenic atrophy showed little evidence of impairment of normal immune responses, there was a high frequency of autoantibody formation. There is thus an association between widespread immunological disturbances, notably autoimmunity, and splenic atrophy.
在14例因脾萎缩导致脾功能减退且血涂片有相关证据的患者中，已证实存在多种免疫异常。通过放射学检查确认了脾脏大小减小，通过研究化学损伤的自体红细胞的存活和转归来证明脾脏吞噬功能受损。其中8例患者有肠道吸收不良，其余患者自身免疫性疾病的发生率较高。尽管脾萎缩患者几乎没有正常免疫反应受损的证据，但自身抗体形成的频率较高。因此，广泛的免疫紊乱，尤其是自身免疫，与脾萎缩之间存在关联。
