脾脏在实验性自身免疫性甲状腺炎中的作用。
The role of the spleen in experimental autoimmune thyroiditis.
作者信息
Weetman A P, McGregor A M, Rennie D P, Hassman R, Hall R
出版信息
Clin Exp Immunol. 1984 Apr;56(1):135-42.
We have investigated the role of the spleen in the humoral and cellular immune response of rats with experimental autoimmune thyroiditis (EAT) induced by immunization with thyroglobulin and Freund's complete adjuvant. Animals subjected to splenectomy within 4 days of immunization developed lower thyroglobulin antibody levels and less severe thyroiditis compared to sham operated controls. There was no impairment in the ability of the animals to recover spontaneously from the disease after splenectomy. Together with the results obtained using splenocyte infusions, this suggests that suppressor cell production within the spleen plays only a small part in the normal immunological control which is presumably responsible for spontaneous regression of the disease.
我们研究了脾脏在由甲状腺球蛋白和弗氏完全佐剂免疫诱导的实验性自身免疫性甲状腺炎（EAT）大鼠体液免疫和细胞免疫反应中的作用。与假手术对照组相比，在免疫后4天内接受脾切除术的动物甲状腺球蛋白抗体水平较低，甲状腺炎也较轻。脾切除术后动物从疾病中自发恢复的能力没有受损。结合使用脾细胞输注获得的结果，这表明脾脏内抑制性细胞的产生在正常免疫控制中仅起一小部分作用，而正常免疫控制可能是疾病自发消退的原因。
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