Mabuchi K, Lilienfeld A M, Snell L M
Arch Environ Health. 1979 Sep-Oct;34(5):312-20. doi: 10.1080/00039896.1979.10667423.
Cancer mortality was studied in 1,393 persons exposed to high air concentrations of inorganic arsenicals for varying lengths of time during the manufacture and packaging of pesticides at a plant in Baltimore, Maryland. Employees consisting of 1,050 males and 343 females were traced for the period 1946 to 1977, and vital status was determined for 86.9% of males and 66.8% of females. The observed number of deaths from all and selected causes was compared with the number expected from the Baltimore City mortality experience in terms of the Standardized Mortality Ratio (SMR). A significantly increased SMR was found for lung cancer and anemias in males. The SMR for lung cancer was especially high in males with presumed high exposure to arsenicals. A dose-response relationship was suggested by the SMR for lung cancer which increased with increasing duration of exposure to arsenicals, but no such relationship was evident for nonarsenicals. Although smoking habits could not be examined in the study subjects, the authors believe that the findings provide additional epidemiologic evidence on the respiratory carcinogenicity of occupational exposure to airborne inorganic arsenicals.
在马里兰州巴尔的摩市的一家工厂，对1393名在农药生产和包装过程中暴露于高浓度无机砷环境不同时长的人员的癌症死亡率进行了研究。这些员工包括1050名男性和343名女性，在1946年至1977年期间接受追踪，确定了86.9%的男性和66.8%的女性的生命状态。根据标准化死亡比（SMR），将所有原因和特定原因的观察死亡人数与巴尔的摩市死亡率经验预期的死亡人数进行了比较。发现男性肺癌和贫血的SMR显著升高。在假定高砷暴露的男性中，肺癌的SMR尤其高。肺癌的SMR显示出剂量反应关系，随着砷暴露时间的增加而升高，但非砷暴露情况没有明显的这种关系。尽管无法在研究对象中检查吸烟习惯，但作者认为这些发现为职业性接触空气中无机砷的呼吸道致癌性提供了更多的流行病学证据。
