与在铜冶炼厂接触砷有关的癌症。
Cancers related to exposure to arsenic at a copper smelter.
作者信息
Enterline P E, Day R, Marsh G M
机构信息
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
出版信息
Occup Environ Med. 1995 Jan;52(1):28-32. doi: 10.1136/oem.52.1.28.
OBJECTIVE
This is an update of an earlier study on the relation between exposure to arsenic in air and deaths from respiratory cancer. The purpose was to verify earlier findings of a supralinear dose response relation and to examine relations with other cancers, particularly those reported in studies on drinking water.
METHODS
An earlier study of 2802 men who worked at a copper smelter for a year or more during the period 1940-64 and who were followed up for deaths during the period 1941-76 was updated until 1986. Estimates of exposure for the period 1977-1984 were added.
RESULTS AND CONCLUSIONS
The additional follow up confirms the earlier finding that at low doses the increments in death rates for respiratory cancer for a given increment in dose are greater than at high doses. The additional follow up also shows significant increases in cancer of the large intestine and bone, and SMRs > 150 for cancer of the buccal cavity and pharynx, rectal cancer, and kidney cancer. There was a positive relation between exposure to arsenic in air and kidney and bone cancer, but none for the other cancers, except respiratory.
目的
这是一项关于空气中砷暴露与呼吸道癌死亡之间关系的早期研究的更新。目的是验证早期关于超线性剂量反应关系的发现，并研究与其他癌症的关系，特别是那些在饮用水研究中报告的癌症。
方法
对1940 - 1964年期间在一家铜冶炼厂工作一年或更长时间且在1941 - 1976年期间接受死亡随访的2802名男性进行的早期研究更新至1986年。增加了1977 - 1984年期间的暴露估计值。
结果与结论
额外的随访证实了早期的发现，即在低剂量时，剂量每增加一定量，呼吸道癌死亡率的增加幅度大于高剂量时。额外的随访还显示，大肠癌和骨癌有显著增加，口腔和咽喉癌、直肠癌和肾癌的标准化死亡比（SMR）> 150。空气中砷暴露与肾癌和骨癌之间存在正相关，但除呼吸道癌外，与其他癌症均无相关性。
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