Tsuang M T, Woolson R F, Fleming J A
Arch Gen Psychiatry. 1979 Nov;36(12):1295-301. doi: 10.1001/archpsyc.1979.01780120025002.
We conducted a 30- to 40-year field follow-up of 685 patients with schizophrenia, affective disorders, and nonpsychiatric conditions. Long-term outcome was analyzed in terms of the patients' marital, residential, occupational, and psychiatric status. On the whole, psychiatric patients showed a significantly poorer outcome than the surgical controls. On the basis of long-term outcome, schizophrenia, and affective disorders, selected according to the specified research criteria, were significantly different: schizophrenia definitely showed poorer outcome than affective disorders. However, no significant differences in all four outcome variables were found between mania and depression. We hope that the present data on long-term outcome of the typical cases can be used to compare outcome of other psychiatric disorders, such as undiagnosed psychoses, having mixtures of schizophrenic and affective features. In doing this, we hope to charify our understanding of undiagnosed psychoses and their relationship to schizophrenia and affective disorders.
我们对685例患有精神分裂症、情感障碍和非精神疾病的患者进行了30至40年的实地随访。根据患者的婚姻、居住、职业和精神状态分析长期预后。总体而言，精神科患者的预后明显比外科对照组差。基于长期预后，根据特定研究标准选择的精神分裂症和情感障碍存在显著差异：精神分裂症的预后肯定比情感障碍差。然而，躁狂症和抑郁症在所有四个预后变量上均未发现显著差异。我们希望目前关于典型病例长期预后的数据可用于比较其他精神疾病的预后，如具有精神分裂症和情感特征混合的未确诊精神病。通过这样做，我们希望澄清我们对未确诊精神病及其与精神分裂症和情感障碍关系的理解。
