Tsuang M T, Dempsey G M
Arch Gen Psychiatry. 1979 Nov;36(12):1302-4. doi: 10.1001/archpsyc.1979.01780120032004.
Eighty-five patients with both schizophrenic and affective features at the time of admission to the University of Iowa Psychiatric Hospital between 1934 and 1944 were selected for a 30- to 40-year outcome study. Comparison groups were 200 schizophrenic and 325 affective disorder patients, selected by the Feighner et at criteria, and 160 psychiatric symptom-free surgical patients. We assessed marital, residential, occupational, and psychiatric status to evaluate the outcome of these patients at the time of field follow-up. We used multivariate analysis of covariance to analyze the data by taking admission marital and occupational status into consideration. Patients with schizoaffective disorders had a significantly better outcome than those with schizophrenia, but a significantly poorer outcome than those with affective disorders and surgical conditions. Schizoaffective disorder fell somewhere in between the schizophrenia and mania group. Before final conclusions could be made about the nature of schizoaffective disorders, more research should be done.
1934年至1944年间，爱荷华大学精神病医院收治的85例入院时兼具精神分裂症和情感特征的患者被选入一项为期30至40年的转归研究。对照组为200例精神分裂症患者、325例情感障碍患者（根据费格纳等人的标准选取）以及160例无精神症状的外科手术患者。我们评估了婚姻、居住、职业和精神状态，以评估这些患者在实地随访时的转归情况。我们采用协方差多变量分析，将入院时的婚姻和职业状况考虑在内对数据进行分析。分裂情感性障碍患者的转归明显好于精神分裂症患者，但明显差于情感障碍患者和外科手术患者。分裂情感性障碍处于精神分裂症和躁狂症组之间的某个位置。在对分裂情感性障碍的本质得出最终结论之前，还需要进行更多的研究。
