Philipp M, Beyer J, Happ J, Krause U
Arch Psychiatr Nervenkr (1970). 1979 Jul 4;227(1):71-9. doi: 10.1007/BF00585679.
In a pilot study of 15 depressive patients of the neurotic and endogenous type we could show that some neuroendocrinological parameters are apt to predict the thymoleptic efficacy of lofepramine. These parameters, which were measured with a simple global stimulation test (insulin hypoglycaemia combined with injection of TRH and LHRH), were as follows: high basal blood glucose; high hypoglycaemic blood glucose; high decrease of blood glucose in comparison to the basal level; low basal TSH; low increase of HGH and low increase of cortisol after hypoglycemia. A synopsis of these parameters allowed a correct classification of 14 out of 15 patients according to therapy response and therapy resistance.
在一项针对15名神经症型和内源性抑郁症患者的试点研究中，我们发现某些神经内分泌参数有助于预测洛非帕明的抗抑郁疗效。这些参数通过一项简单的综合刺激试验（胰岛素低血糖联合注射促甲状腺激素释放激素和促黄体生成素释放激素）进行测量，具体如下：基础血糖高；低血糖时血糖高；与基础水平相比血糖下降幅度大；基础促甲状腺激素低；低血糖后生长激素增加量低以及皮质醇增加量低。综合这些参数，15名患者中有14名能够根据治疗反应和治疗抵抗情况得到正确分类。
