Gardi J, Merzenich M, McKean C
Audiology. 1979;18(5):358-81.
The frequency-following response (FFR) is a short-latency scalp-recorded evoked potential elicited by the presentation of low-frequency acoustic stimuli. It is thought to be the result of the synchronous electrical activity in brain stemauditory nuclei to each wave in the acoustic signal. The present investigation constitutes an attempt to determine the generators of the FFR in the cat by analysis of the response and by section of brain stem auditory nuclei and tracts. Among the results were the following: (1) the cochlear nuclei contribute approximately 50% of the amplitude of the scalp-recordedFFR in the cat. (2) The cochlea also makes a significant contribution, accounting for an average of nearly 25% of the response amplitude. (3) The superior olivary nuclei (and/or the nuclei of the lateral lemnisci) account for about 20% of the response amplitude. (4) The contributions from the inferior colliculi (contrary to earlier studies) were found to be relatively insignificant. (5) As a consequence of the existence of multiple generators, the FFR ample area of hair cell excitation for each stimulus frequency involved in the mediation of the FFR, suggestion that scalp-recorded FFRs could be used to ascertain low-frequency hearingsensitivity in uncooperative human subjects.
频率跟随反应（FFR）是一种通过呈现低频听觉刺激而诱发的潜伏期较短的头皮记录诱发电位。它被认为是脑干听觉核中与听觉信号中的每个波同步的电活动的结果。本研究试图通过分析反应以及切断脑干听觉核和神经束来确定猫中FFR的发生器。研究结果如下：（1）在猫中，耳蜗核对头皮记录的FFR幅度贡献约50%。（2）耳蜗也有显著贡献，平均占反应幅度的近25%。（3）上橄榄核（和/或外侧丘系核）占反应幅度的约20%。（4）发现下丘的贡献（与早期研究相反）相对较小。（5）由于存在多个发生器，FFR的幅度反映了参与FFR介导的每个刺激频率的毛细胞兴奋区域，这表明头皮记录的FFR可用于确定不合作人类受试者的低频听力敏感性。
