雌二醇对正常乳腺中孕激素受体的影响及其与泌乳的关系。
Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation.
作者信息
Haslam S Z, Shyamala G
出版信息
Biochem J. 1979 Jul 15;182(1):127-31. doi: 10.1042/bj1820127.
Abstract
Mammary glands of lactating mice, either intact or ovariectomized, do not contain detectable amounts of progesterone receptors and this lack of receptors persists also in tissues of animals treated with oestradiol. In contrast with lactators, mammary glands of virgin mice contain progesterone receptors whose amounts are augmented by oestradiol administration.
摘要
处于哺乳期的小鼠，无论乳腺完整与否或是否已切除卵巢，其乳腺中均未检测到孕酮受体，并且在用雌二醇处理的动物组织中也持续缺乏这种受体。与哺乳期小鼠相反，未生育小鼠的乳腺含有孕酮受体，其含量在用雌二醇处理后会增加。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
EFFECT OF OVARIAN HORMONES ON DURATION OF DNA SYNTHESIS IN CELLS OF THE C3H MOUSE MAMMARY GLAND.卵巢激素对C3H小鼠乳腺细胞DNA合成持续时间的影响。
Exp Cell Res. 1965 Apr;38:13-32. doi: 10.1016/0014-4827(65)90423-4.
3
CHANGES IN THE MAMMARY GLANDS OF RATS AND MICE DURING PREGNANCY, LACTATION AND INVOLUTION. 2. LEVELS OF DEOXYRIBONUCLEIC ACID, AND ALKALINE AND ACID PHOSPHATASES.大鼠和小鼠在怀孕、哺乳及退化过程中乳腺的变化。2. 脱氧核糖核酸、碱性磷酸酶和酸性磷酸酶的水平
J Endocrinol. 1963 Dec;28:17-34. doi: 10.1677/joe.0.0280017.
4
Endocrine control of mammarygland development and function in the C3H/ He Crgl mouse.C3H/He Crgl小鼠乳腺发育和功能的内分泌调控
J Natl Cancer Inst. 1958 Dec;21(6):1039-63.
5
The hormonal control of mammary growth and lactation.乳腺生长与泌乳的激素调控。
Recent Prog Horm Res. 1958;14:219-48; discussion 248-54.
6
A microchemical determination of desoxyribonucleic acid.脱氧核糖核酸的微量化学测定
J Biol Chem. 1952 Sep;198(1):297-303.
7
Variable duration of DNA synthesis in mammary gland cells during pregnancy and lactation of C3H/He mouse.C3H/He小鼠怀孕和哺乳期间乳腺细胞中DNA合成的持续时间可变。
J Cell Physiol. 1967 Apr;69(2):133-42. doi: 10.1002/jcp.1040690203.
8
Interactions of 6,7-3H-17 -estradiol with the mouse lactating mammary tissue in vivo and in vitro.
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9
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Endocrinology. 1972 Apr;90(4):1041-5. doi: 10.1210/endo-90-4-1041.
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