静脉注射后红霉素的胆汁排泄
Biliary excretion of erythromycin after parenteral administration.
作者信息
Chelvan P, Hamilton-Miller J M, Brumfitt W
出版信息
Br J Clin Pharmacol. 1979 Sep;8(3):233-5. doi: 10.1111/j.1365-2125.1979.tb01007.x.
Abstract
1 The biliary excretion of erythromycin has been studied following parenteral administration in 23 patients. 2 Mean bile levels of the drug were approximately ten times higher than corresponding serum concentrations 1 h after i.v. (erythromycin lactobionate) and i.m. (erythromycin ethylsuccinate) injection. 3 Thus, unlike many antimicrobial agents, these compounds are well concentrated in the bile.
摘要
对23例患者进行肠外给药后，研究了红霉素的胆汁排泄情况。
静脉注射（乳糖酸红霉素）和肌内注射（琥乙红霉素）1小时后，药物的平均胆汁水平比相应的血清浓度高约10倍。
因此，与许多抗菌药物不同，这些化合物在胆汁中浓度很高。
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本文引用的文献
1
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Surg Gynecol Obstet. 1955 May;100(5):571-4.
2
Factors affecting the absorption and biliary excretion of erythromycin and two of its derivatives in humans.
Clin Pharmacol Ther. 1961 May-Jun;2:308-12. doi: 10.1002/cpt196123308.
3
[Biliary elimination of antibiotics].
Rev Int Hepatol. 1957;7(4):287-303.
4
The biliary excretion of erythromycin (ilotycin).
Surg Gynecol Obstet. 1956 Mar;102(3):355-7.
5
Antibacterial activity of 2'-esters of erythromycin.红霉素2'-酯的抗菌活性
Appl Microbiol. 1969 Aug;18(2):159-65. doi: 10.1128/am.18.2.159-165.1969.
6
Excretion of erythromycin and its enhanced activity in urine against gram-negative bacilli with alkalinization.
J Lab Clin Med. 1968 Dec;72(6):916-23.
7
Transient bacteremia and endocarditis prophylaxis. A review.短暂性菌血症与心内膜炎预防：综述
Medicine (Baltimore). 1977 Jan;56(1):61-77.
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