牛眼鳞状细胞癌：淋巴细胞对植物血凝素和肿瘤抗原的反应。
Bovine ocular squamous-cell carcinoma: lymphocyte response to phytohaemagglutinin and tumour antigen.
作者信息
Jennings P A, Lavin M F, Hughes D J, Spradbrow P B
出版信息
Br J Cancer. 1979 Oct;40(4):608-14. doi: 10.1038/bjc.1979.226.
Abstract
The presence of ocular squamous-cell carcinomas in cattle was associated with significantly lower blastogenic response of peripheral-blood cultures to PHA than that of age-matched control cattle. The difference in blastogenic response was more marked when the external diameter of the tumour exceeded 2 cm. Cattle with aquamous-cell carcinomas had cell-mediated immunity against tumour extracts, as measured by the leucocyte adherence inhibition (LAI) microassay. The LAI reaction against tumour extracts was directly proportional to the general level of cell-mediated immunity as demonstrated by the lymphoproliferative response to PHA.
摘要
牛眼部鳞状细胞癌的存在与外周血培养物对PHA的增殖反应显著低于年龄匹配的对照牛有关。当肿瘤外径超过2厘米时，增殖反应的差异更为明显。通过白细胞黏附抑制（LAI）微量测定法测量，患有鳞状细胞癌的牛对肿瘤提取物具有细胞介导的免疫反应。针对肿瘤提取物的LAI反应与细胞介导免疫的总体水平成正比，这一点通过对PHA的淋巴细胞增殖反应得到证明。
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Evidence for transformation of human B lymphocytes by PHA.PHA诱导人B淋巴细胞转化的证据。
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