Lavin M F, Kidson C
Nucleic Acids Res. 1977 Nov;4(11):4015-22. doi: 10.1093/nar/4.11.4015.
Phytohemagglutinin stimulated human lymphocytes exhibit a 20 fold increase in DNA repair synthesis following ionizing radiation damage compared to the level of repair in unstimulated cells. The peak of repair synthesis coincides with that for DNA replication. Stimulated lymphocytes provide a relatively simple assay for ionizing radiation repair defects.
与未受刺激的细胞相比,植物血凝素刺激的人类淋巴细胞在受到电离辐射损伤后,其DNA修复合成水平增加了20倍。修复合成的峰值与DNA复制的峰值一致。受刺激的淋巴细胞为检测电离辐射修复缺陷提供了一种相对简单的方法。