人类淋巴细胞中电离辐射诱导的DNA损伤修复
Repair of ionizing radiation induced DNA damage in human lymphocytes.
作者信息
Lavin M F, Kidson C
出版信息
Nucleic Acids Res. 1977 Nov;4(11):4015-22. doi: 10.1093/nar/4.11.4015.
Abstract
Phytohemagglutinin stimulated human lymphocytes exhibit a 20 fold increase in DNA repair synthesis following ionizing radiation damage compared to the level of repair in unstimulated cells. The peak of repair synthesis coincides with that for DNA replication. Stimulated lymphocytes provide a relatively simple assay for ionizing radiation repair defects.
摘要
与未受刺激的细胞相比，植物血凝素刺激的人类淋巴细胞在受到电离辐射损伤后，其DNA修复合成水平增加了20倍。修复合成的峰值与DNA复制的峰值一致。受刺激的淋巴细胞为检测电离辐射修复缺陷提供了一种相对简单的方法。
相似文献
1
Repair of ionizing radiation induced DNA damage in human lymphocytes.人类淋巴细胞中电离辐射诱导的DNA损伤修复
Nucleic Acids Res. 1977 Nov;4(11):4015-22. doi: 10.1093/nar/4.11.4015.
2
Screening for deficits in DNA repair by the response of irradiated human lymphocytes to phytohemagglutinin.
Cancer Res. 1977 Oct;37(10):3594-8.
3
Excision repair of pyrimidine dimers in human peripheral blood lymphocytes: comparison between mitogen stimulated and unstimulated cells.人类外周血淋巴细胞中嘧啶二聚体的切除修复：有丝分裂原刺激细胞与未刺激细胞的比较
Mutat Res. 1988 Sep;194(2):143-50. doi: 10.1016/0167-8817(88)90016-8.
4
Increased rate of repair of ultraviolet-induced DNA strand breaks in mitogen stimulated lymphocytes.
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 May;41(5):483-91. doi: 10.1080/09553008214550561.
5
Ionizing radiation damage repair: a role for topoisomerases?
Mutagenesis. 2001 Jul;16(4):365-8. doi: 10.1093/mutage/16.4.365.
6
Lymphocytes in ataxia telangiectasia: implications of the DNA repair defect.
Clin Immunol Immunopathol. 1978 Jul;10(3):325-9. doi: 10.1016/0090-1229(78)90188-5.
7
DNA repair capacity after gamma-irradiation and expression profiles of DNA repair genes in resting and proliferating human peripheral blood lymphocytes.伽马射线照射后人类外周血淋巴细胞的DNA修复能力及静止和增殖状态下DNA修复基因的表达谱
DNA Repair (Amst). 2002 Mar 28;1(3):237-50. doi: 10.1016/s1568-7864(01)00019-2.
8
Radiation sensitivity of lymphocytes from human blood and from the thoracic duct.
Acta Radiol Ther Phys Biol. 1976 Apr;15(2):177-82. doi: 10.3109/02841867609132718.
9
Influence of glutathione levels on radiation-induced chromosomal DNA damage and repair in human peripheral lymphocytes.谷胱甘肽水平对人外周血淋巴细胞辐射诱导的染色体DNA损伤及修复的影响
Mutat Res. 2009 Apr 30;675(1-2):23-8. doi: 10.1016/j.mrgentox.2009.02.001. Epub 2009 Feb 10.
10
Effects of pulsed electric fields on DNA of human lymphocytes.脉冲电场对人淋巴细胞DNA的影响。
Cell Biol Toxicol. 2006 Nov;22(6):409-15. doi: 10.1007/s10565-006-0105-1. Epub 2006 Aug 5.
引用本文的文献
1
New research highlights: Impact of chronic ingestion of white kidney beans ( L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats.新研究亮点：长期摄入白芸豆（菜豆属变种贝迪亚）对Wistar大鼠小肠双糖酶活性的影响。
Toxicol Rep. 2017 Dec 15;5:46-55. doi: 10.1016/j.toxrep.2017.12.016. eCollection 2018.
2
Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells.抗凋亡蛋白 BCL2 下调癌细胞中的 DNA 末端连接。
J Biol Chem. 2010 Oct 15;285(42):32657-70. doi: 10.1074/jbc.M110.140350. Epub 2010 Aug 10.
3
Cellular and molecular aspects of immune system aging.免疫系统衰老的细胞和分子层面
Mol Cell Biochem. 1981 Jul;37(3):137-56. doi: 10.1007/BF02354883.
4
Inhibitory effect of partial cystectomy on experimental carcinogenesis in the urinary bladder.部分膀胱切除术对膀胱实验性致癌作用的抑制效果
J Cancer Res Clin Oncol. 1983;106(2):123-9. doi: 10.1007/BF00395390.
5
Altered temporal expression of DNA repair in hypermutable Bloom's syndrome cells.高突变型布卢姆综合征细胞中DNA修复的时间表达改变。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):757-61. doi: 10.1073/pnas.81.3.757.
6
Isolation and characterization of monoclonal antibodies directed against the DNA repair enzyme uracil DNA glycosylase from human placenta.针对人胎盘DNA修复酶尿嘧啶DNA糖基化酶的单克隆抗体的分离与鉴定
Proc Natl Acad Sci U S A. 1983 Oct;80(19):5822-6. doi: 10.1073/pnas.80.19.5822.
7
Regulation of DNA repair in serum-stimulated xeroderma pigmentosum cells.血清刺激的着色性干皮病细胞中DNA修复的调控
J Cell Biol. 1984 Oct;99(4 Pt 1):1275-81. doi: 10.1083/jcb.99.4.1275.
8
Modification of N-methyl-N-nitrosourea-induced urinary bladder carcinogenesis in rats following stimulation of urothelial proliferation by a partial cystectomy.部分膀胱切除术后刺激尿路上皮增殖对N-甲基-N-亚硝基脲诱导的大鼠膀胱癌发生的影响
J Cancer Res Clin Oncol. 1986;112(1):11-8. doi: 10.1007/BF00394932.
9
Effects of radiation on host-tumor interactions using the multicellular tumor spheroid model.使用多细胞肿瘤球体模型研究辐射对宿主-肿瘤相互作用的影响。
Cancer Immunol Immunother. 1986;23(1):20-4. doi: 10.1007/BF00205550.
10
Development of N-butyl-N-(hydroxybutyl)-nitrosamine-induced tumors in the partially resected, proliferating rat urinary bladder in dependence upon the time of onset of stimulated DNA synthesis.
Urol Res. 1990;18(5):319-22. doi: 10.1007/BF00300779.
本文引用的文献
1
Chromosome aberrations and T-cell survival in human lymphocytes.
Radiat Res. 1974 Dec;60(3):482-8.
2
Kinetics of unscheduled DNA synthesis induced by ionizing radiation in human lymphocytes.
Radiat Res. 1969 Aug;39(2):400-12.
3
Defective repair replication of DNA in xeroderma pigmentosum.着色性干皮病中DNA修复复制缺陷。
Nature. 1968 May 18;218(5142):652-6. doi: 10.1038/218652a0.
4
DNA polymerase and DNA replication during lymphocyte transformation.淋巴细胞转化过程中的DNA聚合酶与DNA复制
Cancer Res. 1970 Oct;30(10):2514-20.
5
Factors influencing chromosome aberration yields in the human peripheral leukocyte system.影响人类外周血白细胞系统中染色体畸变率的因素。
Mutat Res. 1969 Sep-Oct;8(2):383-99. doi: 10.1016/0027-5107(69)90016-5.
6
Quantitative study of radiation effects in phytohaemagglutinin-stimulated leukocyte cultures.植物血凝素刺激的白细胞培养物中辐射效应的定量研究。
Int J Radiat Biol Relat Stud Phys Chem Med. 1969;16(2):157-65. doi: 10.1080/09553006914551171.
7
Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA.着色性干皮病细胞在修复其DNA紫外线损伤时不执行第一步的证据。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1035-41. doi: 10.1073/pnas.64.3.1035.
8
9
Size of repair patches in the DNA of ultraviolet-irradiated HeLa cells.紫外线照射的HeLa细胞DNA中修复补丁的大小。
Biochim Biophys Acta. 1972 Jul 20;272(3):361-72. doi: 10.1016/0005-2787(72)90389-9.
10
Genes which increase chromosomal instability in somatic cells and predispose to cancer.在体细胞中增加染色体不稳定性并易患癌症的基因。
Prog Med Genet. 1972;8:61-101.
Zotero 插件