Iaina A, Solomon S, Eliahou H E
Lancet. 1975 Jul 26;2(7926):157-9. doi: 10.1016/s0140-6736(75)90060-4.
The effectiveness of beta-adrenergic blockade in preventing acute renal failure (A.R.F.) in rats was studied in the hypoxia model produced by unilateral nephrectomy and clamping of the contralateral renal artery for 70 minutes. Beta-adrenergic blockade effectively reduced the severity of A.R.F. in this experimental model. Treatment with a combination of propranolol and a synthetic angiotensin-II competitive inhibitor (P113) produced no further improvement. These results are consistent with the view that intrarenal release of renin is to some extent involved in the pathogenesis of A.R.F.
在单侧肾切除并钳夹对侧肾动脉70分钟所产生的缺氧模型中，研究了β-肾上腺素能阻滞剂预防大鼠急性肾衰竭（ARF）的有效性。在该实验模型中，β-肾上腺素能阻滞剂有效降低了ARF的严重程度。普萘洛尔与合成的血管紧张素II竞争性抑制剂（P113）联合治疗未产生进一步改善。这些结果与肾内肾素释放某种程度上参与ARF发病机制的观点一致。
