Scopinaro N, Gianetta E, Civalleri D, Bonalumi U, Bachi V
Br J Surg. 1979 Sep;66(9):618-20. doi: 10.1002/bjs.1800660906.
After a successful trial of bilio-pancreatic bypass in dogs, a clinical study has been completed in 18 patients followed for more than 1 year. The operation has been modified to achieve the best weight reduction, and forming the bilio-pancreatic tract of equal length to the alimentary tract with a short common ileal tract, the average weight loss as a percentage of the preoperative body weight was 24.1 +/- 5.4 per cent (mean +/- s.d.) at 6 months and 33.7 +/- 4.1 per cent at 12 months. The only immediate complication was a wound dehiscence, and there were no late complications. Liver function studies showed the absence of hepatic deterioration and liver biopsies showed improvement of liver morphology 1 year after the operation. It is suggested that this procedure may be an alternative to jejuno-ileal bypass in the management of obesity.
在犬类身上成功进行胆胰转流试验后，已对18例患者完成了一项为期1年多的临床研究。该手术已进行改良以实现最佳减重效果，通过构建与消化道长度相等的胆胰通道并带有短的共同回肠段，术后6个月时平均体重减轻占术前体重的百分比为24.1±5.4%（均值±标准差），12个月时为33.7±4.1%。唯一的即刻并发症是伤口裂开，且无晚期并发症。肝功能研究显示无肝脏恶化情况，肝脏活检显示术后1年肝脏形态有所改善。有人提出，在肥胖症治疗中，该手术可能是空肠回肠转流术的一种替代方法。
