人类对脑膜炎球菌的免疫力。五、用C群脑膜炎球菌多糖免疫对带菌状态的影响。
Human immunity to the meningococcus. V. The effect of immunization with meningococcal group C polysaccharide on the carrier state.
作者信息
Gotschlich E C, Goldschneider I, Artenstein M S
出版信息
J Exp Med. 1969 Jun 1;129(6):1385-95. doi: 10.1084/jem.129.6.1385.
Abstract
Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individuals with the exception of two recruits injected with A polysaccharide. During the 6 wk period of observation, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 per cent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci; 4.6, 24, and 31 per cent respectively.
摘要
将纯化的脑膜炎球菌多糖给予新兵。接受C群多糖的145名男性和注射A群多糖的53名男性均未观察到不良反应。除两名注射A群多糖的新兵外，所有个体血清中均出现了血凝和杀菌活性。在6周的观察期内，在所研究的三个连队中，未接种疫苗的新兵感染C群脑膜炎球菌的比例分别为38%、42%和69%。接种C群多糖疫苗的个体感染C群脑膜炎球菌的比例明显较低，分别为4.6%、24%和31%。
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