Silverman S J, Moore G T, Roessler W G
J Bacteriol. 1969 May;98(2):443-6. doi: 10.1128/jb.98.2.443-446.1969.
Monkeys were immunized with enterotoxin and enterotoxoid by intracutaneous injection or by feeding. Identical schedules were used to compare the effectiveness of the two antigens and the two routes. Enterotoxin administered intracutaneously was the most effective antigen, whereas oral administration of enterotoxoid was least effective. Intracutaneous injection of toxoid and oral feeding of toxin were intermediate and not too dissimilar in effectiveness. Antibody titers and protection persisted for at least 1 year at a relatively high level. Monkeys that had preimmunization hemagglutinins showed an anamnestic response after immunization. The development of protection and the appearance of antibodies subsequent to feeding toxin or toxoid suggest that ingestion of food contaminated by staphylococci or their metabolites may be one cause for the appearance of antitoxin in the serum of supposedly unexposed animals and man.
通过皮内注射或喂食的方式，用肠毒素和类毒素对猴子进行免疫。采用相同的免疫程序来比较两种抗原和两种途径的效果。皮内注射的肠毒素是最有效的抗原，而口服类毒素的效果最差。皮内注射类毒素和口服毒素的效果处于中间水平，且二者效果差异不大。抗体滴度和保护作用在相对较高水平上持续至少1年。预先存在血凝素的猴子在免疫后出现了回忆反应。喂食毒素或类毒素后保护作用的产生以及抗体的出现表明，摄入被葡萄球菌或其代谢产物污染的食物可能是在假定未接触过的动物和人类血清中出现抗毒素的一个原因。
