Shinagawa K, Ishibashi M, Yamamoto H, Kunita N, Hisa K
Jpn J Med Sci Biol. 1974 Dec;27(6):309-14. doi: 10.7883/yoken1952.27.309.
Immune doses of staphylococcal enterotoxin B to rabbits were studied by comparing the efficiency of various immunization schedules. It was experienced that even two subcutaneous injections each with such a small dose as 10 mug of enterotoxin B, the primary one with Freund's complete adjuvant and a booster one without adjuvant, could stimulate a rabbit to develop the antibody to a satisfactorily high titer determined by agar gel diffusion and passive hemagglutination.
通过比较不同免疫方案的效果，研究了给兔子注射免疫剂量的葡萄球菌肠毒素B的情况。经验表明，即使每次皮下注射小至10微克肠毒素B这样的剂量，首次注射用弗氏完全佐剂，加强注射不用佐剂，进行两次注射，也能刺激兔子产生抗体，通过琼脂凝胶扩散法和被动血凝法测定，抗体效价能达到令人满意的高水平。
