Tohyama M, Sakai K, Touret M, Salvert D, Jouvet M
Brain Res. 1979 Nov 2;176(2):215-31. doi: 10.1016/0006-8993(79)90980-6.
The descending projections to the spinal cord arising from the dorsolateral pontine tegmentum and brain stem raphe nuclei have been investigated by means of the horseradish peroxidase (HRP) technique. Particular attention was taken to clarify the cells of origin and the funicular trajectory of these spinal projections. After injections of HRP into the spinal cord, a significant of HRP labeled neurons were observed in the following dorsolateral pontine tegmental structures: (1) an area ventral to the nucleus cuneiformis; (2) principal locus coeruleus; (3) locus coeruleus a; (4) locuse subcoeruleus; (5) Kölliker-Fuse nucleus; and (6) nucleus parabrachialis lateralis. As a rule, the projections are ipsilateral and descendaphe-spinal projections, we have demonstrated that the nucleus raphe dorsalis also sends axons to the cervical segment of the spinal cord. Furthermore, in accord with previous reports, HRP labeled cells were also identified in the nucleus raphe magnus, pallidus and obscurus, but not in the nucleus raphe centralis superior and pontis. On the whole the present study further clarified the organization of spinal projections from the dorsolateral pons and raphe nuclei and provided some additional anatomical data for the physiology of the tegmentospinal and raphe-spinal projections.
运用辣根过氧化物酶（HRP）技术，对源自脑桥背外侧被盖和脑干中缝核向脊髓的下行投射进行了研究。特别关注了这些脊髓投射的起源细胞和纤维束轨迹。将HRP注入脊髓后，在以下脑桥背外侧被盖结构中观察到大量HRP标记的神经元：（1）楔状核腹侧区域；（2）蓝斑主核；（3）蓝斑a；（4）蓝斑下核；（5） Kölliker-Fuse核；以及（6）外侧臂旁核。通常，这些投射是同侧的且下行，关于中缝脊髓投射，我们已证明中缝背核也向脊髓颈段发送轴突。此外，与先前报道一致，在中缝大核、中缝苍白核和中缝隐核中也鉴定出了HRP标记的细胞，但在中缝中央上核和中缝脑桥核中未发现。总体而言，本研究进一步阐明了脑桥背外侧和中缝核的脊髓投射组织，并为被盖脊髓和中缝脊髓投射的生理学提供了一些额外的解剖学数据。
