Newman D B
J Hirnforsch. 1985;26(4):385-418.
The purpose of this study was to determine whether pontine and mesencephalic reticulospinal nuclei like those of the medulla, can be differentiated on the basis of neuronal morphology. Accordingly, neurons of the various pontine and mesencephalic brainstem reticulospinal nuclei (BRN) of adult albino or hooded rats were either backfilled with horseradish peroxidase (HRP) from spinal injections, stained with a Nissl method or impregnated with a Golgi-Kopsch variant. The results suggest that at least 13 BRN can be distinguished in the pons and mesencephalon of the rat on the basis of neuronal morphology. The dendritic arborizations (DA) of neurons in nucleus reticularis (NR) pedunculopontinus pars compacta (RPpc), NR pedunculopontinus pars dissipatus (RPpd), NR cuneiformis (RCf) and NR subcuneiformis (RScf) are radially symmetrical. The DA of neurons in NR pontis caudalis pars beta (RPoCb) and alpha (RPoCa), as well as those of NR subcoeruleus (RSc) and the A5 cell group, exhibit a pronounced dorsomedial to ventrolateral slant. The dendrites of locus coeruleus (LC) neurons slant from dorsolateral to ventromedial. The DA of NR pontis oralis pars medialis (RPoOm) neurons course medially, while those of NR pontis oralis pars lateralis (RPoOl) course laterally. The DA of Kolliker-Fuse neurons (KF) course horizontally. Finally, the DA of the nucleus raphe dorsalis (RaD) are either symmetrically multipolar or fusiform. The neurons of RPoCb, RPpc, KF and RCf project to the spinal cord with a strong ipsilateral predominance, while those of LC, RSc, RPoOm and RPpd project to the spinal cord with a weak ipsilateral predominance. The axons of A5, RPoOl and RaD neurons exhibit no lateral predominance in their spinal projections. Finally, RPoCa neurons, as well as neurons in RScf, project to the spinal cord with a strong contralateral predominance. The neurons of RPoCb, RPoCa, RPoOl, RPpd and RScf project to the spinal cord via the mlf and sulcomarginal fasciculus. The neurons of RSc, KF, RPoOm, RPpc and RCf project to the spinal cord via the lateral funiculus.
本研究的目的是确定脑桥和中脑的网状脊髓核是否像延髓的那样，能够根据神经元形态进行区分。因此，对成年白化或带帽大鼠的各种脑桥和中脑脑干网状脊髓核（BRN）的神经元，要么通过脊髓注射用辣根过氧化物酶（HRP）进行逆向填充，用尼氏法染色，要么用高尔基-科普施变体进行浸染。结果表明，基于神经元形态，在大鼠的脑桥和中脑至少可以区分出13个BRN。脚桥核致密部（RPpc）、脚桥核弥散部（RPpd）、楔形核（RCf）和亚楔形核（RScf）中神经元的树突分支（DA）呈放射状对称。脑桥尾侧核β部（RPoCb）和α部（RPoCa）以及亚蓝斑核（RSc）和A5细胞群中神经元的DA表现出明显的从背内侧到腹外侧的倾斜。蓝斑（LC）神经元的树突从背外侧向腹内侧倾斜。脑桥嘴侧核内侧部（RPoOm）神经元的DA向内侧走行，而脑桥嘴侧核外侧部（RPoOl）神经元的DA向外侧走行。柯利克-富斯核（KF）神经元的DA水平走行。最后，背侧中缝核（RaD）的DA要么是对称多极的，要么是梭形的。RPoCb、RPpc、KF和RCf的神经元以强烈的同侧优势投射到脊髓，而LC、RSc、RPoOm和RPpd的神经元以微弱的同侧优势投射到脊髓。A5、RPoOl和RaD神经元的轴突在其脊髓投射中没有侧方优势。最后，RPoCa神经元以及RScf中的神经元以强烈的对侧优势投射到脊髓。RPoCb、RPoCa、RPoOl、RPpd和RScf的神经元通过内侧纵束和缘束投射到脊髓。RSc、KF、RPoOm、RPpc和RCf的神经元通过外侧索投射到脊髓。
