脑去甲肾上腺素能系统的选择性损伤对大鼠巴比妥酸盐耐受性发展的影响。

The effect of selective lesions of brain noradrenergic systems on the development of barbiturate tolerance in rats.

作者信息

Tabakoff B, Ritzmann R F, Oltmans G A

出版信息

Brain Res. 1979 Nov 2;176(2):327-36. doi: 10.1016/0006-8993(79)90987-9.

Abstract

A method for chronic infusion of barbiturates into the central nervous system of rats was developed and used to study the importance of noradrenergic systems in the development of barbiturate tolerance. Destruction of noradrenergic neurons by intraventricular administration of 6-hydroxydopamine or by specific lesions of the dorsal or ventral noradrenergic bundles prevented the development of barbiturate tolerance without altering the animal's response to the acute administration of barbiturate.

摘要

一种将巴比妥酸盐慢性注入大鼠中枢神经系统的方法被研发出来，并用于研究去甲肾上腺素能系统在巴比妥酸盐耐受性形成中的重要性。通过脑室内注射6-羟基多巴胺或对背侧或腹侧去甲肾上腺素能束进行特定损伤来破坏去甲肾上腺素能神经元，可阻止巴比妥酸盐耐受性的形成，而不会改变动物对急性注射巴比妥酸盐的反应。