Cooper D K
Thorax. 1969 Jul;24(4):383-90. doi: 10.1136/thx.24.4.383.
Transplantation of the heart and both lungs is being considered as a clinical possibility in several surgical centres today. This paper reviews the experimental development of surgical techniques in this field. In the 1940s Demikhov in the U.S.S.R. succeeded in developing a technique by which he could carry out cardiopulmonary transplantation without the use of any artificial means of recipient support during the procedure. He obtained survivors for up to six days; late deaths occurred mainly from pulmonary complications. The techniques and results of subsequent workers using hypothermia or pump-oxygenator support are reviewed. Recent work has focused on the problem of the return of spontaneous respiration following denervation of the lungs which, of necessity, occurs during this procedure.
如今，心脏和双肺移植在多个外科中心正被视为一种临床可行方案。本文回顾了该领域外科技术的实验发展历程。20世纪40年代，苏联的德米霍夫成功研发出一种技术，借助该技术他能够在手术过程中不使用任何人工受体支持手段的情况下进行心肺移植。他使实验对象存活了长达六天；后期死亡主要源于肺部并发症。本文还回顾了后续研究人员使用低温或体外循环支持的技术及成果。近期的研究工作聚焦于肺部去神经支配后自主呼吸恢复的问题，而在这个手术过程中，肺部去神经支配是必然会发生的。
