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1
A template-selective inhibitor of in vitro transcription.一种体外转录的模板选择性抑制剂。
Proc Natl Acad Sci U S A. 1969 Feb;62(2):514-20. doi: 10.1073/pnas.62.2.514.
2
Purification of a positive regulatory subunit from phage SP01-modified RNA polymerase.从噬菌体SP01修饰的RNA聚合酶中纯化一种正调控亚基。
Nature. 1977 Nov 3;270(5632):28-32. doi: 10.1038/270028a0.
3
Bacteriophage SPO1 DNA- and RNA-directed protein synthesis in vitro: the effect of TF1, a template-selective transcription inhibitor.噬菌体SPO1在体外的DNA和RNA指导的蛋白质合成：模板选择性转录抑制剂TF1的作用。
Mol Gen Genet. 1975;137(2):161-9. doi: 10.1007/BF00341682.
4
Restriction fragment analysis of bacteriophage SPP1 in vitro transcription by host RNA polymerase.宿主RNA聚合酶对噬菌体SPP1体外转录的限制片段分析。
J Virol. 1978 Oct;28(1):95-105. doi: 10.1128/JVI.28.1.95-105.1978.
5
Transcription of DNA of T2 bacteriophage by RNA polymerase of calf thymus.用小牛胸腺的RNA聚合酶转录T2噬菌体的DNA
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6
Effects of the transciption inhibitory protein, TF1, on phage SP01 promoter complex formation and stability.转录抑制蛋白TF1对噬菌体SP01启动子复合物形成及稳定性的影响。
J Mol Biol. 1977 Dec 25;117(4):825-42. doi: 10.1016/s0022-2836(77)80001-6.
7
Initiation, release, and reinitiation of RNA chains by bacteriophage-T3-induced polymerase from T3 DNA templates (E. coli-guanosine triphosphate terminus-purified polymerase).噬菌体T3诱导的聚合酶以T3 DNA模板（大肠杆菌-三磷酸鸟苷末端-纯化的聚合酶）起始、释放和重新起始RNA链。
Proc Natl Acad Sci U S A. 1972 Jan;69(1):55-9. doi: 10.1073/pnas.69.1.55.
8
RNA polymerase mutants blocked in sporulation.在芽孢形成过程中受阻的RNA聚合酶突变体。
Nature. 1970 Aug 29;227(5261):906-9. doi: 10.1038/227906a0.
9
Transcription of late phage RNA by T7 RNA polymerase.T7 RNA聚合酶对晚期噬菌体RNA的转录。
Nature. 1970 Dec 19;228(5277):1160-2. doi: 10.1038/2281160a0.
10
Coupling of replication to transcription in vitro.体外复制与转录的偶联。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2288-91. doi: 10.1073/pnas.69.8.2288.

引用本文的文献

1
Determinants of affinity and mode of DNA binding at the carboxy terminus of the bacteriophage SPO1-encoded type II DNA-binding protein, TF1.噬菌体SPO1编码的II型DNA结合蛋白TF1羧基末端的DNA结合亲和力和模式的决定因素。
J Bacteriol. 1994 Mar;176(5):1364-73. doi: 10.1128/jb.176.5.1364-1373.1994.
2
Bacteriophage SPO1 structure and morphogenesis. III. SPO1 proteins and synthesis.噬菌体SPO1的结构与形态发生。III. SPO1蛋白与合成。
J Virol. 1983 Apr;46(1):260-9. doi: 10.1128/JVI.46.1.260-269.1983.
3
Nucleic acid synthesis in Bacillus subtilis infected with bacteriophage beta-22.被噬菌体β - 22感染的枯草芽孢杆菌中的核酸合成。
J Virol. 1970 Oct;6(4):381-92. doi: 10.1128/JVI.6.4.381-392.1970.
4
Transcription during the development of bacteriophage phi29: definition of "early" and "late" phi29 ribonucleic acid.噬菌体φ29发育过程中的转录：“早期”和“晚期”φ29核糖核酸的定义
J Virol. 1973 Jan;11(1):9-16. doi: 10.1128/JVI.11.1.9-16.1973.
5
Site-specific DNA binding by the bacteriophage SP01-encoded type II DNA-binding protein.噬菌体SP01编码的II型DNA结合蛋白的位点特异性DNA结合
EMBO J. 1985 May;4(5):1345-9. doi: 10.1002/j.1460-2075.1985.tb03783.x.
6
TF1, the bacteriophage SPO1-encoded type II DNA-binding protein, is essential for viral multiplication.TF1是噬菌体SPO1编码的II型DNA结合蛋白，对病毒繁殖至关重要。
J Virol. 1988 Sep;62(9):3455-62. doi: 10.1128/JVI.62.9.3455-3462.1988.
7
Construction and properties of a temperature-sensitive mutation in the gene for the bacteriophage SPO1 DNA-binding protein TF1.噬菌体SPO1 DNA结合蛋白TF1基因中温度敏感突变的构建与特性
J Bacteriol. 1990 Aug;172(8):4672-81. doi: 10.1128/jb.172.8.4672-4681.1990.
8
Cyanobacterial DNA-binding protein related to Escherichia coli HU.与大肠杆菌HU相关的蓝细菌DNA结合蛋白
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1917-20. doi: 10.1073/pnas.73.6.1917.
9
Bacteriophage SPO1 DNA- and RNA-directed protein synthesis in vitro: the effect of TF1, a template-selective transcription inhibitor.噬菌体SPO1在体外的DNA和RNA指导的蛋白质合成：模板选择性转录抑制剂TF1的作用。
Mol Gen Genet. 1975;137(2):161-9. doi: 10.1007/BF00341682.
10
Bacteriophages of Bacillus subtilis.枯草芽孢杆菌噬菌体
Bacteriol Rev. 1975 Sep;39(3):257-315. doi: 10.1128/br.39.3.257-315.1975.

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INFECTIVITY OF DNA ISOLATED FROM BACILLUS SUBTILIS BACTERIOPHAGE, SP82.从枯草芽孢杆菌噬菌体SP82中分离出的DNA的感染性
J Mol Biol. 1964 Dec;10:438-51. doi: 10.1016/s0022-2836(64)80065-6.
2
THE POSSIBLE ROLE OF RECOMBINATION IN THE INFECTION OF COMPETENT BACILLUS SUBTILIS BY BACTERIOPHAGE DEOXYRIBONUCLEIC ACID.重组在噬菌体脱氧核糖核酸感染感受态枯草芽孢杆菌中的可能作用
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Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli.大肠杆菌中一种酶催化的脱氧核糖核酸指导的核糖核酸合成。
Proc Natl Acad Sci U S A. 1962 Jan 15;48(1):81-94. doi: 10.1073/pnas.48.1.81.
4
Genetic regulatory mechanisms in the synthesis of proteins.蛋白质合成中的遗传调控机制。
J Mol Biol. 1961 Jun;3:318-56. doi: 10.1016/s0022-2836(61)80072-7.
5
On the transcription of the tryptophan operon in Escherichia coli. 3. Multicistronic messenger RNA and polarity for transcription.关于大肠杆菌中色氨酸操纵子的转录。3. 多顺反子信使核糖核酸与转录极性
J Mol Biol. 1965 Aug;13(1):169-82. doi: 10.1016/s0022-2836(65)80087-0.
6
The operators controlled by the lambda phage repressor.由λ噬菌体阻遏物控制的操纵基因。
Proc Natl Acad Sci U S A. 1968 Aug;60(4):1282-7. doi: 10.1073/pnas.60.4.1282.
7
In vitro repression of phage lambda DNA transcription by a partially purified repressor from lysogenic cells.用来自溶源细胞的部分纯化阻遏物对噬菌体λDNA转录进行体外抑制。
Proc Natl Acad Sci U S A. 1968 Mar;59(3):1016-23. doi: 10.1073/pnas.59.3.1016.
8
Deoxyribonucleic acid replication and expression of early and late bacteriophage functions in Bacillus subtilis.枯草芽孢杆菌中脱氧核糖核酸的复制以及噬菌体早期和晚期功能的表达
J Virol. 1967 Feb;1(1):86-91. doi: 10.1128/JVI.1.1.86-91.1967.
9
Repression of early messenger transcription in the development of a bacteriophage.噬菌体发育过程中早期信使转录的抑制
J Mol Biol. 1967 Dec 14;30(2):435-40.
10
Interaction of rifamycin with bacterial RNA polymerase.利福霉素与细菌RNA聚合酶的相互作用。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):667-73. doi: 10.1073/pnas.61.2.667.

一种体外转录的模板选择性抑制剂。

A template-selective inhibitor of in vitro transcription.

作者信息

Wilson D L, Geiduschek E P

出版信息

Proc Natl Acad Sci U S A. 1969 Feb;62(2):514-20. doi: 10.1073/pnas.62.2.514.

DOI:10.1073/pnas.62.2.514
PMID:4978743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC277828/
Abstract

A macromolecular factor, TF1, has been isolated from bacteriophage SP01-infected B. subtilis. TF1 selectively inhibits in vitro transcription of SP01 and related viral DNA. Evidence is presented regarding these properties of the repressor-like TF1: (1) template and conformational specificity; (2) interaction with DNA rather than RNA polymerase; (3) trypsin sensitivity; (4) reversibility of action; and (5) ability to block initiation, but not propagation, of RNA synthesis.

摘要

一种大分子因子TF1已从噬菌体SP01感染的枯草芽孢杆菌中分离出来。TF1能选择性地抑制SP01及相关病毒DNA的体外转录。本文提供了关于类阻遏物TF1这些特性的证据：（1）模板和构象特异性；（2）与DNA而非RNA聚合酶相互作用；（3）对胰蛋白酶敏感；（4）作用的可逆性；以及（5）阻断RNA合成起始而非延伸的能力。