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分离出一种参与人体对淋球菌感染免疫反应的淋病奈瑟菌抗原。

Isolation of an antigen of Neisseria gonorrhoeae involved in the human immune response to gonococcal infection.

作者信息

Schmale J D, Danielsson D G, Smith J F, Lee L, Peacock W L

出版信息

J Bacteriol. 1969 Aug;99(2):469-71. doi: 10.1128/jb.99.2.469-471.1969.

DOI:10.1128/jb.99.2.469-471.1969
PMID:4980063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250040/
Abstract

Ion-exchange chromatography was used to isolate a fraction from disrupted gonococci which reacts with sera from patients with gonococcal disease in complement-fixation and gel-diffusion tests. This antigenic fraction was shown to be the same as that previously described as having been isolated by gel filtration. The method reported here has the advantage of greater rapidity of isolation together with some improvement in purity.

摘要

离子交换色谱法用于从破碎的淋球菌中分离出一种组分，该组分在补体结合试验和凝胶扩散试验中能与淋病患者的血清发生反应。已证明这种抗原性组分与先前描述的通过凝胶过滤分离得到的组分相同。本文报道的方法具有分离速度更快以及纯度有所提高的优点。

相似文献

1
Isolation of an antigen of Neisseria gonorrhoeae involved in the human immune response to gonococcal infection.分离出一种参与人体对淋球菌感染免疫反应的淋病奈瑟菌抗原。
J Bacteriol. 1969 Aug;99(2):469-71. doi: 10.1128/jb.99.2.469-471.1969.
2
Antigens of Neisseria gonorrhoeae: characterization by gel filtration, complement fixation, and agar-gel diffusion of antigens of gonococcal protoplasm.淋病奈瑟菌抗原：通过凝胶过滤、补体结合以及淋病奈瑟菌原生质抗原的琼脂凝胶扩散进行特性鉴定
J Bacteriol. 1969 Mar;97(3):1012-7. doi: 10.1128/jb.97.3.1012-1017.1969.
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Reactivity of two selected antigens of Neisseria gonorrhoeae.淋病奈瑟菌两种选定抗原的反应性。
Appl Microbiol. 1969 Sep;18(3):337-9. doi: 10.1128/am.18.3.337-339.1969.
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Quantitation of serum antibodies to surface antigens of Neisseria gonorrhoeae with radiolabeled protein A of Staphylococcus aureus.用金黄色葡萄球菌放射性标记蛋白A定量检测淋病奈瑟菌表面抗原的血清抗体
J Infect Dis. 1976 Oct;134(4):317-23. doi: 10.1093/infdis/134.4.317.
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Reactivity of two gonococcal antigens in an automated microhemagglutination procedure.两种淋球菌抗原在自动微量血凝试验中的反应性。
Appl Microbiol. 1970 Dec;20(6):907-9. doi: 10.1128/am.20.6.907-909.1970.
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Human immunity to Neisseria gonorrhoeae: acquired serum opsonic antibodies.
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Studies on circulating gonococcal antibodies and antigens.
Can J Microbiol. 1978 Feb;24(2):109-11. doi: 10.1139/m78-020.
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Gonococcal salpingitis is less likely to recur with Neisseria gonorrhoeae of the same principal outer membrane protein antigenic type.由具有相同主要外膜蛋白抗原类型的淋病奈瑟菌引起的淋菌性输卵管炎复发的可能性较小。
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The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae.B 群脑膜炎球菌疫苗 Bexsero 可诱导针对淋病奈瑟菌的抗体。
Clin Infect Dis. 2019 Sep 13;69(7):1101-1111. doi: 10.1093/cid/ciy1061.
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Studies on the influence of antigens on the results with the gonococcal complement fixation test in patients with uncomplicated and complicated gonorrhoea.关于抗原对单纯性和复杂性淋病患者淋球菌补体结合试验结果影响的研究。
Acta Derm Venereol. 1977;57(6):547-552.

引用本文的文献

1
Particulate Fractions of Neisseria gonorrhoeae.淋病奈瑟菌的颗粒部分。
Infect Immun. 1971 Apr;3(4):624-32. doi: 10.1128/iai.3.4.624-632.1971.
2
Nature and Heterogeneity of the Antigens of Neisseria gonorrhoeae Involved in the Serum Bactericidal Reaction.淋病奈瑟菌血清杀菌反应相关抗原的性质和异质性。
Infect Immun. 1970 Aug;2(2):162-8. doi: 10.1128/iai.2.2.162-168.1970.
3
Identification of a gonococcal antigen important in the human immune response.鉴定淋球菌抗原在人类免疫反应中的重要性。
Infect Immun. 1970 Feb;1(2):207-8. doi: 10.1128/iai.1.2.207-208.1970.
4
A comparison of serological tests for the diagnosis of gonorrhoea.用于淋病诊断的血清学检测比较。
Br J Vener Dis. 1971 Dec;47(6):448-51. doi: 10.1136/sti.47.6.448.
5
Serological tests for gonorrhoea.淋病血清学检测
Br Med J. 1972 Mar 4;1(5800):584.
6
Human antibody response to lipopolysaccharides from Neisseria gonorrhoeae.人类对淋病奈瑟菌脂多糖的抗体反应。
J Clin Pathol. 1972 Jan;25(1):56-9. doi: 10.1136/jcp.25.1.56.
7
Gonococcal infections. Laboratory, clinical and epidemiological aspects.淋球菌感染。实验室、临床及流行病学方面
West J Med. 1974 Jun;120(6):456-62.
8
Quantitative determination of antibody to gonococcal pili. Changes in antibody levels with gonococcal infection.淋菌菌毛抗体的定量测定。淋菌感染时抗体水平的变化。
J Clin Invest. 1973 Nov;52(11):2896-909. doi: 10.1172/JCI107486.
9
Transformation of lymphocytes in gonorrhea before and after therapy.淋病治疗前后淋巴细胞的转化
Infect Immun. 1973 Oct;8(4):503-9. doi: 10.1128/iai.8.4.503-509.1973.
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Antigenic analysis of Neisseria gonorrhoeae by crossed immunoelectrophoresis.用交叉免疫电泳法对淋病奈瑟菌进行抗原分析。
Infect Immun. 1976 Apr;13(4):1273-88. doi: 10.1128/iai.13.4.1273-1288.1976.

本文引用的文献

1
Antigens of Neisseria gonorrhoeae: characterization by gel filtration, complement fixation, and agar-gel diffusion of antigens of gonococcal protoplasm.淋病奈瑟菌抗原：通过凝胶过滤、补体结合以及淋病奈瑟菌原生质抗原的琼脂凝胶扩散进行特性鉴定
J Bacteriol. 1969 Mar;97(3):1012-7. doi: 10.1128/jb.97.3.1012-1017.1969.
2
Preparation of cell walls and protoplasm of Neisseria with the Ribi cell fractionator.用里比细胞破碎机制备淋病奈瑟菌的细胞壁和原生质体。
J Bacteriol. 1969 Mar;97(3):1009-11. doi: 10.1128/jb.97.3.1009-1011.1969.