Ward M E, Glynn A A
J Clin Pathol. 1972 Jan;25(1):56-9. doi: 10.1136/jcp.25.1.56.
Red cells coated with lipopolysaccharides from three different strains of Neisseria gonorhoeae have been used as antigens in a haemagglutination test for gonococcal antibodies. For each strain the geometric mean titre in sera from 50 male and 25 female patients was significantly higher than that in 50 normal controls. The most useful smooth strain, G1, picked out 84% of females and 46% of males from a group of patients known to have gonorrhoea, but only gave 2% positives among controls. The rough strain, G2, gave 10% positives in controls and 31% in patients. The results suggest that the method is worth developing further as a diagnostic test and that strain differences are important. False positives were probably due to cross-reacting antibodies.
用来自三种不同淋病奈瑟菌菌株的脂多糖包被的红细胞作为抗原，用于淋病奈瑟菌抗体的血凝试验。对于每种菌株，50名男性和25名女性患者血清中的几何平均滴度显著高于50名正常对照者的几何平均滴度。最有用的光滑菌株G1，从一组已知患有淋病的患者中检出了84%的女性和46%的男性，但在对照中仅有2%呈阳性。粗糙菌株G2在对照中的阳性率为10%，在患者中的阳性率为31%。结果表明，该方法作为一种诊断试验值得进一步开发，且菌株差异很重要。假阳性可能是由于交叉反应抗体所致。
