局灶性青霉素损伤对兔皮层神经元对假定神经递质反应的影响。

Effects of a focal penicillin lesion on responses of rabbit cortical neurones to putative neurotransmitters.

作者信息

Clarke G, Hill R G

出版信息

Br J Pharmacol. 1972 Mar;44(3):435-41. doi: 10.1111/j.1476-5381.1972.tb07281.x.

DOI:10.1111/j.1476-5381.1972.tb07281.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665816/

Abstract

Epileptogenic foci were generated in rabbit cerebral cortex by the topical application of penicillin.2. Responses to iontophoretically applied putative neurotransmitters were compared in cortical neurones firing spontaneously with those driven by applied excitant substances, both before and after establishing the penicillin focus.3. In the presence of the spiking focus, currents of gamma-aminobutyric acid, which normally produced 100% depression of neuronal firing, were ineffective.4. In the same situation, currents of (+/-)-homocysteic acid, glutamate and acetylcholine produced predominantly depolarization block responses, and hence depression of firing.5. It is concluded that an epileptogenic focus can alter the responses of rabbit cortical neurones to microiontophoretically applied neurotransmitter substances. Possible mechanisms for the spread of seizure activity are discussed.

摘要

通过在兔大脑皮层局部应用青霉素来产生致痫灶。
在建立青霉素病灶之前和之后，比较了皮层神经元对离子电泳施加的假定神经递质的反应，这些神经元既有自发放电的，也有由施加的兴奋物质驱动的。
在有棘波病灶的情况下，通常能使神经元放电完全抑制的γ-氨基丁酸电流无效。
在相同情况下，（±）-高半胱氨酸、谷氨酸和乙酰胆碱的电流主要产生去极化阻滞反应，从而导致放电抑制。
得出的结论是，致痫灶可改变兔皮层神经元对微离子电泳施加的神经递质物质的反应。并讨论了癫痫活动传播的可能机制。