Promchainant C
Mutat Res. 1975 Apr;28(1):107-12. doi: 10.1016/0027-5107(75)90320-6.
Human leukocytes treated with bleomycin (BLM) for clinical use, at concentrations of 0.1, 0.5, 1.0, 10 and 50 mug/ml were studied. Both chromosome- and chromatid-type aberrations were observed. The groups of larger chromosomes were more affected at every concentration. At dosages from 0.1 to 10 mug/ml no significant difference of effects on chromosomes was observed. However, a dose-difference of about 500 times showed significant differences in effect both on the degree of chromosomal aberration and on mitotic indices.
研究了临床使用的博来霉素（BLM）以0.1、0.5、1.0、10和50微克/毫升的浓度处理人白细胞的情况。观察到了染色体型和染色单体型畸变。在每个浓度下，较大染色体组受影响更大。在0.1至10微克/毫升的剂量下，未观察到对染色体影响的显著差异。然而，约500倍的剂量差异在染色体畸变程度和有丝分裂指数方面均显示出显著的效应差异。
