平阳霉素对染色体的影响：染色体畸变的一种可能结构基础。

Effects of pingyanymycin on chromosomes: a possible structural basis for chromosome aberration.

作者信息

Heng H Q, Chen W Y, Wang Y C

机构信息

Cell Biology Research Laboratory, Peking Normal University, Beijing, P.R. China.

出版信息

Mutat Res. 1988 May;199(1):199-205. doi: 10.1016/0027-5107(88)90246-1.

DOI:10.1016/0027-5107(88)90246-1

PMID:2452349

Abstract

Pingyanymycin (PYM), and antitumor-antibiotic complex which belongs to the bleomycin family can induce "G2-free chromatin" and "uncompleted-packing-mitotic figures" (UPM) at increased frequency after treatment of cultured human lymphocytes. PYM can also induce an extraordinarily high frequency of chromosomal breaks but few sister-chromatid exchanges (SCE) in the same experiment, which is similar to the action of bleomycin. To solve this remarkable contradiction we presume that the UPM is related to a basic mechanism for producing chromosomal aberrations. Our results also show that various steps of the chromosomal cycle can be affected by certain chemical agents, and these treatments lead to chromosomal aberrations. Thus, other testing systems should be used in addition to the SCE system.

摘要

平阳霉素（PYM）是一种属于博来霉素家族的抗肿瘤抗生素复合物，在处理培养的人淋巴细胞后，能以增加的频率诱导“无G2期染色质”和“未完成包装的有丝分裂图像”（UPM）。在同一实验中，PYM还能诱导极高频率的染色体断裂，但很少有姐妹染色单体交换（SCE），这与博来霉素的作用相似。为了解决这一显著矛盾，我们推测UPM与产生染色体畸变的基本机制有关。我们的结果还表明，染色体周期的各个步骤可受到某些化学试剂的影响，这些处理会导致染色体畸变。因此，除了SCE系统外，还应使用其他检测系统。