Balaji M, Sasikala K
Department of Zoology, Bharathiar University, Coimbatore, India.
Mutat Res. 1993 Jan;301(1):13-7. doi: 10.1016/0165-7992(93)90050-6.
Chromosomal aberrations, sister-chromatid exchanges and mitotic indices were observed in human peripheral leukocytes, treated with four different concentrations of malathion (0.02, 0.2, 2 and 20 micrograms/ml), an organophosphate pesticide, added to the culture medium at 0, 24 and 48 h after culture initiation. These cultures showed a dose-dependent increase in the frequency of chromosomal aberration as well as sister-chromatid exchanges. There was a significant decrease in mitotic index at all concentrations.
在人外周血白细胞中观察了染色体畸变、姐妹染色单体交换和有丝分裂指数。将四种不同浓度（0.02、0.2、2和20微克/毫升）的马拉硫磷（一种有机磷农药）添加到培养基中，分别在培养开始后的0、24和48小时进行处理。这些培养物显示出染色体畸变频率以及姐妹染色单体交换呈剂量依赖性增加。在所有浓度下，有丝分裂指数均显著降低。
