同源和异源抗毒素在实验性白喉和破伤风中的治疗效果。
The therapeutic effect of homologous and heterologous antitoxins in experimental diphtheria and tetanus.
作者信息
Smith J W, Schallibaum E M
出版信息
Br J Exp Pathol. 1970 Feb;51(1):73-80.
Antitoxic sera against diphtheria and tetanus toxins were prepared in mice, guinea-pigs, rabbits and monkeys. The therapeutic effect of the antitoxins was compared in mice injected subcutaneously with tetanus toxin and in guinea-pigs injected intracutaneously with diphtheria toxin. The comparisons were made by varying the time interval between the injection of constant doses of toxin and antitoxin. Homologous antitoxin was not found to have any superiority over heterologous antitoxin in controlling the effects of the toxin injections. It is suggested that when used therapeutically the dose of homologous antitoxin should be the same as that of heterologous antitoxin.
针对白喉毒素和破伤风毒素的抗毒素血清是在小鼠、豚鼠、兔子和猴子体内制备的。在皮下注射破伤风毒素的小鼠和皮内注射白喉毒素的豚鼠中比较了抗毒素的治疗效果。通过改变恒定剂量的毒素和抗毒素注射之间的时间间隔进行比较。在控制毒素注射的效果方面，未发现同源抗毒素比异源抗毒素有任何优势。建议在治疗使用时，同源抗毒素的剂量应与异源抗毒素的剂量相同。
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