豚鼠中叠氮化钠和硝普钠的支气管扩张及血管舒张活性比较
Comparison of the bronchodilator and vasodilator activity of sodium azide and sodium nitroprusside in the guinea-pig.
作者信息
Jamieson D D, Taylor K M
出版信息
Clin Exp Pharmacol Physiol. 1979 Sep-Oct;6(5):515-25. doi: 10.1111/j.1440-1681.1979.tb00034.x.
Abstract
- Sodium azide and sodium nitroprusside are potent dilators of the intact guinea-pig tracheal preparation in vitro. 2. Both substances are bronchodilators in the anaesthetized guinea-pig in vivo when administered intravenously or by aerosol inhalation. 3. Sodium azide and sodium nitroprusside are also potent vasodilators in the guinea pig. 4. At all doses and by route of administration, including aerosol inhalation, the hypotensive effect predominates over bronchodilatation.
摘要
- 叠氮化钠和硝普钠在体外是完整豚鼠气管制剂的强效扩张剂。2. 当通过静脉注射或气雾剂吸入给药时，这两种物质在体内麻醉的豚鼠中都是支气管扩张剂。3. 叠氮化钠和硝普钠在豚鼠中也是强效血管扩张剂。4. 在所有剂量和给药途径下，包括气雾剂吸入，降压作用均强于支气管扩张作用。
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