Kalenberg S, Satchell D G
Clin Exp Pharmacol Physiol. 1979 Sep-Oct;6(5):549-59. doi: 10.1111/j.1440-1681.1979.tb00038.x.
(1) Inhibitory responses to field stimulation have been determined in strip preparations from the thoracic, middle and cervical regions of the trachea and in the tracheal tube preparation. (2) The adrenergic neurone blocking drug guanethidine was found to cause a partial reduction of the amplitudes of the responses in all preparations. (3) The guanethidine-resistant inhibitory responses were resistant to pentolinium but were abolished by tetrodotoxin. The data favours the existence of non-adrenergic inhibitory intramural nerves in the guinea-pig trachea. (4) Inhibitory responses have been determined in the presence and absence of guanethidine at frequencies ranging from 2 to 60 Hz. This has enabled the combined responses to stimulation of both adrenergic and non-adrenergic nerves to be compared with the response to stimulation of non-adrenergic nerves alone at each frequency and in each preparation. (5) The contribution of each innervation to the combined inhibitory response was frequency dependent. The adrenergic innervation was more effective at lower frequencies and the non-adrenaration is discussed. Its origin is considered.
(1) 已在气管胸段、中段和颈段的条带标本以及气管插管标本中测定了对场刺激的抑制反应。(2) 发现肾上腺素能神经元阻断药物胍乙啶可使所有标本中的反应幅度部分降低。(3) 对胍乙啶耐药的抑制反应对潘托铵有抗性，但可被河豚毒素消除。这些数据支持豚鼠气管中存在非肾上腺素能抑制性壁内神经。(4) 已在有和没有胍乙啶的情况下，在2至60赫兹的频率范围内测定了抑制反应。这使得能够将肾上腺素能神经和非肾上腺素能神经刺激的联合反应与每个频率和每个标本中单独刺激非肾上腺素能神经的反应进行比较。(5) 每种神经支配对联合抑制反应的贡献是频率依赖性的。肾上腺素能神经支配在较低频率下更有效，并且对非肾上腺素能神经支配进行了讨论。考虑了其起源。
