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1
Adenosine deaminase antagonizes inhibitory responses to adenosine and non-adrenergic, non-cholinergic inhibitory nerve stimulation in isolated preparations of guinea-pig trachea.腺苷脱氨酶可拮抗豚鼠气管离体标本中对腺苷以及非肾上腺素能、非胆碱能抑制性神经刺激的抑制反应。
Br J Pharmacol. 1984 Oct;83(2):323-5. doi: 10.1111/j.1476-5381.1984.tb16490.x.
2
Purine receptors in trachea: studies with adenosine deaminase and dipyridamole.气管中的嘌呤受体：腺苷脱氨酶和双嘧达莫的研究
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3
Use of purine nucleotide and nucleoside metabolising enzymes as tools to determine the presence of purinergic nerve transmission in smooth muscle.使用嘌呤核苷酸和核苷代谢酶作为工具来确定平滑肌中嘌呤能神经传递的存在。
Adv Exp Med Biol. 1989;253B:435-40. doi: 10.1007/978-1-4684-5676-9_64.
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A non-adrenergic inhibitory nervous pathway in guinea-pig trachea.豚鼠气管中的一条非肾上腺素能抑制性神经通路。
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5
Inhibitory responses to nicotine and transmural stimulation in hyoscine-treated guinea-pig isolated trachealis: an electrical and mechanical study.东莨菪碱处理的豚鼠离体气管对尼古丁和跨壁刺激的抑制反应：电生理和力学研究
Br J Pharmacol. 1987 Apr;90(4):733-44. doi: 10.1111/j.1476-5381.1987.tb11227.x.
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The inhibitory innervation of the guinea-pig trachea: a study of its adrenergic and non-adrenergic components.豚鼠气管的抑制性神经支配：对其肾上腺素能和非肾上腺素能成分的研究。
Clin Exp Pharmacol Physiol. 1979 Sep-Oct;6(5):549-59. doi: 10.1111/j.1440-1681.1979.tb00038.x.
7
The effects of vasoactive intestinal peptide (VIP) antagonists, and VIP and peptide histidine isoleucine antisera on non-adrenergic, non-cholinergic relaxations of tracheal smooth muscle.血管活性肠肽（VIP）拮抗剂、VIP及肽组氨酸异亮氨酸抗血清对气管平滑肌非肾上腺素能、非胆碱能舒张作用的影响。
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Adenosine modulation of non-adrenergic non-cholinergic neurotransmission in isolated guinea-pig atria.腺苷对离体豚鼠心房非肾上腺素能非胆碱能神经传递的调节作用
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A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species.非肾上腺素能、非胆碱能神经刺激和外源性应用ATP对来自不同脊椎动物物种的多种平滑肌制剂的兴奋和抑制作用的比较。
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10
Presynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea.豚鼠气管中神经介导的胆碱能兴奋性和非肾上腺素能非胆碱能抑制性反应的突触前α肾上腺素能受体调节
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引用本文的文献

1
Relaxant innervation of the guinea-pig trachealis: demonstration of capsaicin-sensitive and -insensitive vagal pathways.豚鼠气管的舒张性神经支配：辣椒素敏感和不敏感迷走神经通路的证明。
J Physiol. 1993 Jan;460:719-39. doi: 10.1113/jphysiol.1993.sp019496.
2
Proceedings of the British Pharmacological Society. Ireland, 6th-8th July, 1988. Abstracts.英国药理学会会议记录。爱尔兰，1988年7月6日至8日。摘要
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3
The effects of vasoactive intestinal peptide (VIP) antagonists, and VIP and peptide histidine isoleucine antisera on non-adrenergic, non-cholinergic relaxations of tracheal smooth muscle.血管活性肠肽（VIP）拮抗剂、VIP及肽组氨酸异亮氨酸抗血清对气管平滑肌非肾上腺素能、非胆碱能舒张作用的影响。
Br J Pharmacol. 1989 Mar;96(3):513-20. doi: 10.1111/j.1476-5381.1989.tb11847.x.

本文引用的文献

1
Purine receptors in the trachea: is there a receptor for ATP?气管中的嘌呤受体：是否存在ATP受体？
Br J Pharmacol. 1980 Dec;70(4):512-4. doi: 10.1111/j.1476-5381.1980.tb09768.x.
2
Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways.血管活性肠肽：豚鼠气道非肾上腺素能舒张的一种可能递质。
Science. 1980 Dec 12;210(4475):1252-3. doi: 10.1126/science.6254154.
3
Non-adrenergic, non-cholinergic nerves in mammalian airways: their function and the role of purines.哺乳动物气道中的非肾上腺素能、非胆碱能神经：它们的功能及嘌呤的作用
Comp Biochem Physiol C Comp Pharmacol. 1982;72(2):189-96. doi: 10.1016/0306-4492(82)90083-1.
4
Effects of some purine derivatives on the guinea-pig trachea and their interaction with drugs that block adenosine uptake.某些嘌呤衍生物对豚鼠气管的作用及其与阻断腺苷摄取药物的相互作用。
Br J Pharmacol. 1976 May;57(1):51-7. doi: 10.1111/j.1476-5381.1976.tb07655.x.

腺苷脱氨酶可拮抗豚鼠气管离体标本中对腺苷以及非肾上腺素能、非胆碱能抑制性神经刺激的抑制反应。

Adenosine deaminase antagonizes inhibitory responses to adenosine and non-adrenergic, non-cholinergic inhibitory nerve stimulation in isolated preparations of guinea-pig trachea.

作者信息

Satchell D G

出版信息

Br J Pharmacol. 1984 Oct;83(2):323-5. doi: 10.1111/j.1476-5381.1984.tb16490.x.

DOI:10.1111/j.1476-5381.1984.tb16490.x
PMID:6487899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1987106/
Abstract

In guinea-pig isolated tracheal tube preparations treated with dipyridamole, adenosine deaminase antagonized inhibitory responses to adenosine and non-adrenergic, non-cholinergic nerve stimulation. Inhibitory responses to vasoactive intestinal peptide (VIP) were unaffected and hyoscine-sensitive excitatory responses to field stimulation were not reduced. The evidence supports a role of adenosine as an inhibitory neurotransmitter in non-adrenergic, non-cholinergic nerves in trachea.

摘要

在用双嘧达莫处理的豚鼠离体气管制备物中，腺苷脱氨酶可拮抗对腺苷以及对非肾上腺素能、非胆碱能神经刺激的抑制反应。对血管活性肠肽（VIP）的抑制反应未受影响，对场刺激的阿托品敏感兴奋反应也未减弱。这一证据支持腺苷在气管非肾上腺素能、非胆碱能神经中作为抑制性神经递质的作用。