腺苷脱氨酶可拮抗豚鼠气管离体标本中对腺苷以及非肾上腺素能、非胆碱能抑制性神经刺激的抑制反应。
Adenosine deaminase antagonizes inhibitory responses to adenosine and non-adrenergic, non-cholinergic inhibitory nerve stimulation in isolated preparations of guinea-pig trachea.
作者信息
Satchell D G
出版信息
Br J Pharmacol. 1984 Oct;83(2):323-5. doi: 10.1111/j.1476-5381.1984.tb16490.x.
Abstract
In guinea-pig isolated tracheal tube preparations treated with dipyridamole, adenosine deaminase antagonized inhibitory responses to adenosine and non-adrenergic, non-cholinergic nerve stimulation. Inhibitory responses to vasoactive intestinal peptide (VIP) were unaffected and hyoscine-sensitive excitatory responses to field stimulation were not reduced. The evidence supports a role of adenosine as an inhibitory neurotransmitter in non-adrenergic, non-cholinergic nerves in trachea.
摘要
在用双嘧达莫处理的豚鼠离体气管制备物中，腺苷脱氨酶可拮抗对腺苷以及对非肾上腺素能、非胆碱能神经刺激的抑制反应。对血管活性肠肽（VIP）的抑制反应未受影响，对场刺激的阿托品敏感兴奋反应也未减弱。这一证据支持腺苷在气管非肾上腺素能、非胆碱能神经中作为抑制性神经递质的作用。
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本文引用的文献
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2
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