流感嗜血杆菌的辐射敏感性：一种复合反应。
Radiation sensitivity of Haemophilus influenzae: a composite response.
作者信息
Barnhart B J, Cox S H
出版信息
J Bacteriol. 1970 Jul;103(1):9-15. doi: 10.1128/jb.103.1.9-15.1970.
Abstract
The survival of ultraviolet (UV)-irradiated cultures of Haemophilus influenzae Rd is determined by at least two responses: (i) excision-repair ability and (ii) UV-induced cell lysis. An UV-resistant mutant, BC200, has the same capabilities as the wild type, Rd, for excising dimers but does not exhibit lysis. Lytic response is dose-dependent. Relative to the wild type, a lower dose of UV causes lysis of a UV-sensitive mutant, BC100, which is incapable of excising thymine dimers. A lytic protein is present in cultures undergoing lysis. Synthesis of this protein is initiated 45 to 60 min after irradiation. Lysis appears to be due to derepression of a defective prophage which codes for an endolysin-like lytic enzyme.
摘要
流感嗜血杆菌Rd紫外线（UV）照射培养物的存活取决于至少两种反应：（i）切除修复能力和（ii）紫外线诱导的细胞裂解。一种抗紫外线突变体BC200，在切除二聚体方面与野生型Rd具有相同的能力，但不表现出裂解。裂解反应是剂量依赖性的。相对于野生型，较低剂量的紫外线会导致对紫外线敏感的突变体BC100裂解，该突变体无法切除胸腺嘧啶二聚体。正在裂解的培养物中存在一种裂解蛋白。这种蛋白质的合成在照射后45至60分钟开始。裂解似乎是由于编码内溶素样裂解酶的缺陷原噬菌体的去抑制作用。
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