流感嗜血杆菌中紫外线损伤的复制后修复
Postreplication repair of ultraviolet damage in Haemophilus influenzae.
作者信息
Leclerc J E, Setlow J K
出版信息
J Bacteriol. 1972 Jun;110(3):930-4. doi: 10.1128/jb.110.3.930-934.1972.
Abstract
The deoxyribonucleic acid (DNA) synthesized following ultraviolet (UV) irradiation of wild-type (Rd) and recombination-defective strains of Haemophilus influenzae has been analyzed by alkaline sucrose gradient sedimentation. Strain Rd and a UV-resistant, recombination-defective strain Rd(DB117) (rec-) are able to carry out postreplication repair, i.e., close the single-strand gaps in the newly synthesized DNA; in the UV-sensitive, recombination-defective strain DB117, the gaps remain open. The lack of postreplication repair in this strain may be the result of degradation of the newly synthesized DNA.
摘要
利用碱性蔗糖梯度沉降法，对紫外线（UV）照射后的野生型（Rd）和重组缺陷型流感嗜血杆菌菌株所合成的脱氧核糖核酸（DNA）进行了分析。菌株Rd以及一株耐紫外线、重组缺陷型菌株Rd(DB117)（rec-）能够进行复制后修复，即封闭新合成DNA中的单链缺口；而在紫外线敏感的重组缺陷型菌株DB117中，缺口则保持开放状态。该菌株缺乏复制后修复可能是新合成DNA发生降解的结果。
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