Faulkner T P, Hayden J H, Mehta C M, Olson D A, Comstock E G
Clin Toxicol. 1979;15(1):23-37. doi: 10.3109/15563657908992476.
Patients from a polydrug abuse treatment program were titrated with either secobarbital or methaqualone, their primary drug of abuse, to a state of mild intoxication, consisting of lateral and vertical nystagmus, ataxia, slurred speech, and drownsiness. The mean dose required to produce each sign was compared to that determined in a similarly treated control group. Tolerance to secobarbital was more easily demonstrated than tolerance to methaqualone, and nystagmus was the least sensitive indicator of patient tolerance. The individual signs were also cumulated into a graded rating scale of central nervous system depression which would be related to the dose administered. Tolerence was easily demonstrated at the higher stages of toxicity for secobarbital in the overall patient population, but tolerance to methaqualone was only unequivocal in the subjects indicating a relatively high frequency of abuse. Tolerance to methaqualone occurred at the lower stages of toxicity, suggesting that there is a difference between tolerance to secobarbital and tolerance to methaqualone. There was no indication that patients who also abuse alcohol are more tolerant than their patient counterparts. The patients who also had a history of amphetamine abuse, however, were less tolerant than the nonusers of these drugs.
来自多药滥用治疗项目的患者，用速可巴比妥或甲喹酮（他们主要滥用的药物）滴定至轻度中毒状态，表现为水平及垂直眼球震颤、共济失调、言语不清和嗜睡。将产生每种体征所需的平均剂量与在类似治疗的对照组中确定的剂量进行比较。与对甲喹酮的耐受性相比，对速可巴比妥的耐受性更容易表现出来，并且眼球震颤是患者耐受性最不敏感的指标。各个体征还被累积到一个与给药剂量相关的中枢神经系统抑制分级量表中。在总体患者群体中，速可巴比妥在较高毒性阶段很容易表现出耐受性，但甲喹酮的耐受性仅在表明滥用频率相对较高的受试者中明确存在。对甲喹酮的耐受性出现在较低毒性阶段，这表明对速可巴比妥的耐受性和对甲喹酮的耐受性之间存在差异。没有迹象表明同时滥用酒精的患者比其他患者更具耐受性。然而，有苯丙胺滥用史的患者比未使用这些药物的患者耐受性更低。
