McMillan S A, Alderdice J M, McKee C M, Dawson A T, Callender M E, Fulton T T, Haire M
J Clin Pathol. 1987 Feb;40(2):232-6. doi: 10.1136/jcp.40.2.232.
A retrospective analysis of clinical and laboratory features of 102 patients, whose sera contained antibody to mitochondria, showed that primary biliary cirrhosis was diagnosed in 50% of them. Immunofluorescence showed that the sera of the patients with primary biliary cirrhosis all had the M2 antimitochondrial antibody staining pattern. A new staining pattern, designated M2(1), which could be mistaken for the M2 pattern, was not found in any patients with either primary biliary cirrhosis or chronic active hepatitis. Other serological variables such as antibody to mitochondria in IgM class, to multiple nuclear dots, and to the XR antigen, were associated with primary biliary cirrhosis, and taken in association with antimitochondrial antibody of M2 type, contribute to the diagnosis of the disease.
对102例血清中含有线粒体抗体的患者的临床和实验室特征进行回顾性分析，结果显示其中50%被诊断为原发性胆汁性肝硬化。免疫荧光显示，原发性胆汁性肝硬化患者的血清均呈现M2抗线粒体抗体染色模式。在原发性胆汁性肝硬化或慢性活动性肝炎患者中均未发现一种可能被误认为M2模式的新染色模式，即M2(1)。其他血清学变量，如IgM类线粒体抗体、多核点抗体和XR抗原抗体，与原发性胆汁性肝硬化相关，与M2型抗线粒体抗体联合使用有助于该病的诊断。
