Herbert F A, Orford R
Chest. 1979 Nov;76(5):546-51. doi: 10.1378/chest.76.5.546.
Seven young men developed acute pulmonary hemorrhage and edema from the inhalation of powder or fumes of a bisphenol epoxy resin containing tri-mellitic anhydride (TMA) while working in a steel pipe-coating plant. The illness was characterized by cough, hemoptysis, dyspnea, fever, weakness and nausea or vomiting. Chest roentgenograms showed either a bilateral or unilateral pulmonary infiltrate. All patients had a normochromic type of anemia. Pulmonary function studies demonstrated a restrictive defect, hypoxemia, and increased A-a DO2 gradients. Light and electron microscopic studies of lung tissue revealed extensive bleeding into alveoli but no basement membrane deposits were seen and no antiglomerular basement membrane antibodies were detected. The patients improved quickly without treatment. Follow-up studies of six patients three weeks to one year after their illness revealed apparent recovery. A detailed medical survey carried out on all 29 workers currently employed in the plant revealed five additional men had experienced severe recurrent pulmonary problems.
七名年轻男性在一家钢管涂层厂工作时，因吸入含有偏苯三酸酐（TMA）的双酚环氧树脂粉末或烟雾而出现急性肺出血和水肿。该病的特征为咳嗽、咯血、呼吸困难、发热、虚弱以及恶心或呕吐。胸部X线片显示双侧或单侧肺部浸润。所有患者均为正色素性贫血。肺功能研究显示存在限制性缺陷、低氧血症以及肺泡-动脉血氧分压差（A-a DO2）增大。肺组织的光镜和电镜研究显示肺泡内有广泛出血，但未见基底膜沉积物，也未检测到抗肾小球基底膜抗体。患者未经治疗迅速好转。对六名患者在患病后三周至一年进行的随访研究显示明显康复。对该厂目前雇用的所有29名工人进行的详细医学调查发现，另有五名男性曾经历严重的复发性肺部问题。
