猫头鹰猴体内的恶性疟原虫：耐药性与氯喹结合能力
Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity.
作者信息
Fitch C D
出版信息
Science. 1970 Jul 17;169(3942):289-90. doi: 10.1126/science.169.3942.289.
PMID:4988896
Abstract
Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 10(7) liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.
摘要
感染了氯喹敏感型恶性疟原虫的红细胞与氯喹结合时，其表观内在缔合常数为每摩尔1.5×10⁷升。在未感染的红细胞以及感染了氯喹耐药型恶性疟原虫的红细胞中，不存在这种氯喹的高亲和力结合，或其结合存在缺陷。
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