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人血清β脂蛋白中的亚基异质性。

Subunit heterogeneity in human serum beta lipoprotein.

作者信息

Kane J P, Richards E G, Havel R J

出版信息

Proc Natl Acad Sci U S A. 1970 Aug;66(4):1075-82. doi: 10.1073/pnas.66.4.1075.

DOI:10.1073/pnas.66.4.1075
PMID:4990876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335788/
Abstract

The apoprotein of human serum beta lipoprotein has been prepared in a lipid-free and soluble form by a technique of interfacial extraction in the presence of guanidinium hydrochloride and nonionic amphiphile. Gel permeation chromatography of maleylated apobeta lipoprotein separates two protein fractions with different amino acid compositions. The smaller particle has a molecular weight of 2.6 x 10(4).

摘要

通过在盐酸胍和非离子两亲物存在下的界面萃取技术，制备出了无脂质且可溶形式的人血清β脂蛋白载脂蛋白。马来酰化载脂蛋白β脂蛋白的凝胶渗透色谱法分离出了两种具有不同氨基酸组成的蛋白质组分。较小的颗粒分子量为2.6×10⁴。

相似文献

1
Subunit heterogeneity in human serum beta lipoprotein.人血清β脂蛋白中的亚基异质性。
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1075-82. doi: 10.1073/pnas.66.4.1075.
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引用本文的文献

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Proc Natl Acad Sci U S A. 1980 May;77(5):2465-9. doi: 10.1073/pnas.77.5.2465.
2
The low-density-lipoprotein pathway of native and chemically modified low-density lipoproteins isolated from plasma incubated in vitro.从体外孵育的血浆中分离出的天然及化学修饰的低密度脂蛋白的低密度脂蛋白途径。
Biochem J. 1984 Dec 1;224(2):569-76. doi: 10.1042/bj2240569.
3
Assay of total plasma apolipoprotein B concentration in human subjects.人体受试者血浆总载脂蛋白B浓度的测定。
J Clin Invest. 1974 May;53(5):1458-67. doi: 10.1172/JCI107694.
4
A comparaive study of the effects of chemical modification on the immunochemical and optical properties of human plasma low-density lipoprotein(s) and apoproteins.化学修饰对人血浆低密度脂蛋白及载脂蛋白免疫化学和光学性质影响的比较研究
Biochem J. 1973 Jun;133(2):369-82. doi: 10.1042/bj1330369.
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Evidence for the identity of the major apoprotein in low density and very low density lipoproteins in normal subjects and patients with familial hyperlipoproteinemia.正常受试者和家族性高脂蛋白血症患者中低密度脂蛋白和极低密度脂蛋白主要载脂蛋白一致性的证据。
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本文引用的文献

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