Yourassowsky E, Schoutens E, Vanderlinden M P
Chemotherapy. 1975;21(1):45-51. doi: 10.1159/000221843.
215 gram-negative bacilli isolated from clinical materials were tested in vitro against BB-K8 by means of disc diffusion and agar dilution tests; the strains included 40 isolates resistant to gentamicin. Approximately 90% of the strains were inhibited by 3.12 mug/ml or less BB-K8. This antibiotic exhibited a comparable activity, although somewhat inferior, to that of gentamicin, against organisms sensitive to gentamicin. It was considrably more active than gentamicin, and comparable to tobramycin, against the isolates of Klebsiella-Enterobacter-Serratia spp. resistant to gentamicin, but less active than tobramycin against 11 strains of Pseudomonas resistant to gentamicin.
从临床样本中分离出的215株革兰氏阴性杆菌，通过纸片扩散法和琼脂稀释法进行了体外抗BB - K8测试；这些菌株包括40株对庆大霉素耐药的分离株。约90%的菌株被3.12微克/毫升或更低浓度的BB - K8抑制。这种抗生素对庆大霉素敏感的微生物表现出与庆大霉素相当的活性，尽管略逊一筹。对于对庆大霉素耐药的克雷伯菌属 - 肠杆菌属 - 沙雷菌属分离株，它比庆大霉素活性高得多，与妥布霉素相当，但对11株对庆大霉素耐药的铜绿假单胞菌菌株，其活性低于妥布霉素。
