Wiggins G L, McLaughlin J V, Bickham S T, Jones W L, Balows A
Appl Microbiol. 1970 Dec;20(6):893-8. doi: 10.1128/am.20.6.893-898.1970.
The minimal inhibitory concentration (MIC) values of sulfadiazine, penicillin, and rifampin for meningococcal strains isolated from civilians during 1970 were compared. The strains were isolated from various sources and geographical areas and represented several serogroups. The ranges of MIC values were as follows: 0.05 to 20 mg/100 ml for sulfadiazine, 0.01 to 0.4 mug/ml for penicillin, and 0.01 to 0.8 mug/ml for rifampin. There was no significant relationship between MIC values of sensitive or resistant sulfadiazine strains and the MIC values to the other two antimicrobial agents. Comparisons of sulfadiazine MIC values with inhibition zones around sulfathiazole discs showed excellent correlation, provided the strains were separated into sensitive and resistant groups on the basis of growth at 1 mg/100 ml. Regression curves for penicillin and rifampin sensitivity showed homologous sensitive populations with the strains studied.
比较了1970年从平民中分离出的脑膜炎球菌菌株对磺胺嘧啶、青霉素和利福平的最低抑菌浓度(MIC)值。这些菌株来自不同来源和地理区域,代表了几个血清群。MIC值范围如下:磺胺嘧啶为0.05至20mg/100ml,青霉素为0.01至0.4μg/ml,利福平为0.01至0.8μg/ml。敏感或耐药磺胺嘧啶菌株的MIC值与其他两种抗菌药物的MIC值之间无显著关系。将磺胺嘧啶MIC值与磺胺噻唑纸片周围的抑菌圈进行比较,结果显示相关性良好,前提是根据在1mg/100ml浓度下的生长情况将菌株分为敏感和耐药组。青霉素和利福平敏感性的回归曲线显示所研究菌株具有同源敏感群体。