Natvig J B
Immunology. 1970 Jul;19(1):125-35.
Anti-γ-globulin antibodies which show specificity for γG and γG subclass antigens respectively have been detected in human sera. In contrast to most of the subclass antigens which are present in intact γ-globulin, these antigens are only revealed by pepsin digestion. This is the first test system employing anti-γ-globulin antibodies for determining γG subclasses of isolated antibodies and myeloma proteins. These anti-γ-globulins also react strongly with autologous pepsin-digested γG-globulin. The finding of human anti-γ-globulin antibodies with these fine specificities for γG subclasses and autologous γG-globulin suggests that their function is closely related to certain specific-γG antibody populations. The findings show that both γG and γG molecules have subclass specific antigenic structures which are revealed following pepsin digestion.
已在人血清中检测到分别对γG和γG亚类抗原具有特异性的抗γ球蛋白抗体。与完整γ球蛋白中存在的大多数亚类抗原不同,这些抗原只有通过胃蛋白酶消化才能显示出来。这是首个采用抗γ球蛋白抗体来测定分离抗体和骨髓瘤蛋白的γG亚类的检测系统。这些抗γ球蛋白也与自身胃蛋白酶消化的γG球蛋白发生强烈反应。发现具有这些针对γG亚类和自身γG球蛋白的精细特异性的人抗γ球蛋白抗体表明,它们的功能与某些特定的γG抗体群体密切相关。研究结果表明,γG和γG分子都具有亚类特异性抗原结构,这些结构在胃蛋白酶消化后会显现出来。