Waller M, Pierce J C, Hume D M, Mallory J, Millington G A
Clin Exp Immunol. 1970 May;6(5):645-53.
Organ transplant patients who had received ALG, patients with rheumatoid arthritis and normal persons were studied for serum antibodies to horse globulins. Although normal individuals rarely show the presence of anti-horse antibody, rheumatoid patients with high titres of rheumatoid factor usually show anti-horse globulin agglutinins in their IgM globulins and these agglutinins are considered to be a manifestation of their `rheumatoid factors'. These agglutinins are readily absorbable with aggregated human γ-globulin. On the other hand, although most transplant patients administered ALG produce anti-horse antibody, it is usually produced as an IgG globulin and it is not absorbable with aggregated human γ-globulin.
对接受过抗淋巴细胞球蛋白（ALG）治疗的器官移植患者、类风湿性关节炎患者和正常人进行了血清抗马球蛋白抗体研究。虽然正常人很少有抗马抗体，但类风湿因子滴度高的类风湿患者通常在其IgM球蛋白中显示抗马球蛋白凝集素，这些凝集素被认为是其“类风湿因子”的一种表现。这些凝集素很容易被聚合的人γ球蛋白吸收。另一方面，虽然大多数接受ALG治疗的移植患者会产生抗马抗体，但它通常作为IgG球蛋白产生，并且不能被聚合的人γ球蛋白吸收。
