对（NZB×NZW）F1小鼠中C1q结合物质和抗DNA抗体的序贯研究：2月龄小鼠狼疮疾病急性期的证据
Sequential study of C 1 q-binding substances and of anti-DNA antibodies in (NZB X NZW)F1 mice: evidence for an acute phase of the lupus disease in 2-month-old mice.
作者信息
Fournié G J, Gayral-Ta Minh M, Haas S, Pourrat J P, Conte J J
出版信息
Eur J Immunol. 1979 Aug;9(8):652-4. doi: 10.1002/eji.1830090815.
PMID:499331
Abstract
Longitudinal studies of C 1 q and DNA-binding substances were performed in sera from 38 (NZB X NZW)F1 female mice between days 39 and 150 of life. Results suggest a two-phase evolution of circulating immune complexes and anti-DNA antibodies in young (NZB X NZW)F1 mice and show the existence of an acute phase of the disease during the second month of life of these mice.
摘要
对38只（新西兰黑鼠×新西兰白鼠）F1雌性小鼠在出生后第39天至150天期间的血清进行了C1q和DNA结合物质的纵向研究。结果表明，幼年（新西兰黑鼠×新西兰白鼠）F1小鼠体内循环免疫复合物和抗DNA抗体呈两阶段演变，并显示这些小鼠在出生后第二个月存在疾病急性期。
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